GenomeNet

Database: UniProt
Entry: M4AA38_XIPMA
LinkDB: M4AA38_XIPMA
Original site: M4AA38_XIPMA 
ID   M4AA38_XIPMA            Unreviewed;      5074 AA.
AC   M4AA38;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSXMAP00000011332};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000011332, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000011332}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011332};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000011332}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000011332};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000011332}.
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DR   EMBL; AGAJ01019581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000011332; -.
DR   Ensembl; ENSXMAT00000011346; ENSXMAP00000011332; ENSXMAG00000011190.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; M4AA38; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4358   4381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4589   4609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4679   4700       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4817   4838       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4876   4896       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4955   4978       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1215       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1353   1563       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     3772   3799       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5074 AA;  575061 MW;  C6BE12153B82C828 CRC64;
     MAEGADGEEE IQFLRTDDQV VLQCTASILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLSNSSVDEA VDLDKWSSQG GGSRTLLYGH AILLKHTHSN
     MYLSCLTTSR SLTDKLAFDV GLQEDSTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS
     SERYLHLSYA SGDLMVDASF MQTLWTMTPV MSGCELAEGF LIGGYVLRLF HGHMDECLAI
     PCADQGDDQR RVAHYEGGAV CSHARSLWRL EPLRIGWSGG HIKWGQSFRV RHITTGRYLF
     LDEEKGLLLV DPEKANSKMS AFCFRISKEK IEVAQKRDVE GMGIPEIKYG ESMCFVQHVS
     SGLWLTYAAV DAKSARLGPL KRKAILHKEG HMDDALTVAR SQTEESQAAR MIYSTTGLFN
     QFIKGLDALS GKNKSANPPS MPMDAVVLSL QDLIFYFRPP EEELEHEDKQ FKLRSLKNRQ
     NLFQEEGMIS LVLDCIDRLN VYNTAAHFSE YAGEEAAESW KEIVNLLYEL LASLIRGNRT
     NCALFCDNLD WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR
     NHKVLDVLCS LCVCNGVAVR SNQNLITENL LPGRDLLLQT NIINYVTSMR PNIFLGTCEG
     STQYKKWYFE VMVDHVEPFI TSQAYHLRVG WALTEGYSPY PGGGEGWGGN GVGDDLYSYG
     FDGLHLWSGR VPRHVASSSQ HTLAAEDVVS CCLDLSVPSI SFRINGHPVQ GMFENFNLDG
     LFFPVVSFSA GIKLRFLLGG RHGDFKFLPP PGYAPCYEAV LPRDRLRIEP IKEYKHDFND
     VRNLLGPTQS LSHTAFTPCP VDTIQIVLPP HLERIREKLA ENSHELWAVN RIEQGWTYGL
     FRDDNKKMHP CLVDFQSLPE PEKNYNLAMS GETLKTLLAL GCHVGMGDEK AEENLKRTKL
     PKTYMQSNGY KPAPLDLNHV KLTPNQNTLV ERLAENGHNV WARDRVRQGW TYSIVQDILN
     KRNPRLVPYN LLDEKTKKTN RDTVCAAVRT LIGYGYNIEP PDQESSGHGP GSSRGDKIRV
     FRAEKSYAVT QGKWYFEFEA VTVGEMRVGW ARPCVRADTE LGADELAYVF NGFKAQRWHI
     GNEPFGRQWQ SGDVAGCMID LTEMNIMFTL NGEMLISDSG SEMAFKDIEI GEGFIPVCSL
     GLSQVGRINL GQNVSSLRYF TICGLQEGFE PFAINMKRDI TMWFSKSLPQ FITAPTDHPH
     FEISRVDGTV DTPPCLKVTH KTFGSQNANT DLLFFRVSIP IEFHETFKVP AGTTLLTRAL
     TIPEDQVLEV DPNSDFEILK KSATRKEQED DKKEPSVPKE TLAIKNGENE KDASTEKSKK
     KGFLFKAKKA ALITPPPVVP TLPRLVEDVV PDDRDDMDII LNTTTYYYSV RIFAGQEPGG
     VWVGWVTPDY HQYDLHFDLS KVRNVTVTVG DDRGNIHDSI KRSNCYMVWG GEFGNSQQTR
     VSQEDFVIGC LVDLDTGLMT FTANGKEINT FYQVEPNTKL FPAVFVQPSN QNVIQFELGK
     LKNIMPLSAA MFRSERKNPV PQCPPRLDVQ MLTPVIWSRM PNNFLAPETG RVSERLGWMV
     QCMEPLTMMA LHIPEESRCI DILELSERMD LLKFHYHTLK LYGSVCALGN NRVAHALCSH
     VDESQLFYAI ESTYLPGPMR SGFYDLLISM HLESAKRNRL GTNKEFIVPM TDHTRSITLY
     TVKSHALPGV GLTTCLRPKL HFSSVGFVGT DADIYTLSPT IPLQVLKTKA LNMLIEAVQD
     GSQAMRDPVG GSVEFHFVPI LKLISTLLIM GVFDDEDVTH ILKMIEPTVF HTSKSEEPLE
     EPSKLNKQEE PSKAAVVNED EQEVEAEEDE EFEDYGYDDE EEIEEEEELE ETDLNVPQGE
     AVEIDFINGE KGAEETEKET KPVETCGESR EEHLEQGLFQ MKLPESVKLQ MCTLLQYFCD
     CELRHRVEAI AAFSDKFVTQ IQSNQRQRYN ELMMAFTMSA AETARKTREF RSPPQEQVNM
     LMNFKNCPDD EECPVPDEVR DSLLVFHNAL LTHCGVHIDE EEQGEEVDNS LRGRLLRLLE
     RVKKFRQKKV EVELEPQEDK KPSTLQELIS HTMIHWAQES FIQNPELVRM MFSLLHRQYD
     GLGELMRALP KAYTINEVSI QDTMDLLECL GQIRSLLIVQ MGPEEERLII QSIGNIMSNR
     VFYQHPNLMR ALGMHETVME VMVNVLGGGD SKEIRFPRVV TNCCRFLCYF CRISRQNQRS
     MFDHLSYLLQ NSGIGLGMRG STPLDVAAAS CIDNNELALA LQEQDLEMVV KYLAGCGLQS
     CPMLLAKGYP DIGWNPCGGE KYLDFLRFAV FVNGESVEEN ANVVVRLLIR RPECFGPALR
     GEGGNGLLAA VEEAIKISED PARDGPSIKK DRRFPMFGGE EQQEENRVHL GNAIMSFYSA
     LIDLLGRCAP EMHLIQAGKG EALRIRAILR SLVPIEDLVG VISLPVQIPA LGKDNSIIEP
     KMSASFVPDH KAPMVLFLDR VYGIDNQDFL LHVLEVGFLP DMRAAASLDT AAFSTTEMAL
     ALNRYLCTAV LPLITKCAPL FAGSDHRAIM IDSMLHTIYR LSRGRAFTKA QRDIIEECLM
     ALCKNLRPAM LQHLLRRLVF DVPILNEYAK RPLKLLTSHY ERCWKYYCLP NGWANFGVAS
     EEELHLTRKL FWGIFESLAH KKFDAEIFKI SMPCLCAIAG AIPPDYVDAS YSSKTEKKAS
     VDAEGNFDPK PVETTNNSTI IPERLDPFIN RYAEYTHDKW AFEKIQNNWS YGEVLDENAK
     THPMLRPYKT FSEKDKEIYR WPIKESIKAM LAWEWNIEKA REEEESEKKK AASRKISQTA
     QATYDPSHGY SPQPIDISHM ALSRDLQSMA EQLAENYHNT WGRKKKLELQ GKGGGTHPLL
     VPYDTLTAKE KARDREKAYE LLKFLQLNGY AVTRGMKDME SEISSIEKRF AYGFLQKLLK
     WMEIAQEFIA HLEAVVSSGR VEKSPHEQEI KFFAKILMPL INQYFKNHCL YFLSTPAKVL
     GSGGHSSNKE KEMIASIFCK MAALVRHRVS LFGTDASAIV NCLHILARSL DARTVMKSGP
     EIVKAGLRSF FESAADDVEK MVENLKLGKV SKGNQQVKGV SQNINYTTIA LLPVLTSLFD
     HVAQHLFGDD VMLDDLQISC YRIMCSIYSV GTVKNPHVER QRPALGECLA HLAAAMPVAY
     LEPHLNEFNA FSVYTTKTPR ERSILGLPNA VQELCPDIPP LDLLLKEIGD LAESGARYTE
     MPHVIEITLP MLCNYLPRWW ERGPENFPEV EGQLCTEVTS EHLNQLLGSI MKIVVNNLGI
     DEASWMKRLA VFSQPIVSRA KPEMLKSHFI PTMEKLKKRT SKVVAEEDHL RMEGKSEGDE
     EDGTIRDEFA VLCRDLYALY PLLIRYVDNN RARWLTCPDP DAEELFRMVG EVFIFWSKSH
     NFKREEQNFV VMNEINNMSF LTADSKSKMS KGGDTEGGGS DTERTKKKKR GDRYSVQTSL
     IVAALKKMLP IGLNMCSPAD QELINLAKIR YSLRDTDEEV REFLQNNLHL QGKKVDNPSM
     RWQMALYKEM AGKAEDADAP VKVVKRVQEV SAVLYHLEVT EHPFKSKKMV WHKLLSKQRR
     RAVVACFRMT PLYNIARHRA SNMFLEGYKR NWIQTEGCSF EDRMIDDLSK AMEQEEAEEE
     EHERETKPDP LHQLILHFSR TALTEKSKLD TDHLYMAYAD IMAKSCHIGE EEEMAEEMME
     QSEDEMSFEE KEMEKQRLLY QQSRLHNRGA AEMVLQMISA CKGETGPMVS TTLKLGISIL
     NGGNSEVQRK MLEYLKDKKD VGFFLSVQAL MQTCCVLDLN AFERQNKAEG LGMVSEEGTN
     EKVMADDEFT CDLFRFLQLL CEGHNNDFQN YLRTQTGSTT SINVIICTVD YLLRLQESIS
     DFYWYYSGKD IIDDPGKKNF SKAMTVAKQI FNSLTEYIQG PCTGNQQSLA HSRLWDAIVG
     FLHVFAHMMM KLAQPQDSSQ IALLKELLDL QKDMVVMLLS LLEGNIVNGT IARQMVDMLV
     ESSSNVEMIL KFFDMFLKLK DIVASDAFRD YVSDPRGLIS KKDFQKAMDS QKQYSPSEIQ
     FLLSCSEADE NDMINYEEFS NRFQEPAKDI GFNIAVLLTN LSEHVPHDCR LQNFLAQAES
     VLNYFRPFLG RIEIMGASRK IERIYFEISE VNRRQWEMPQ VRESKRQFIF DVVNEGGESE
     KMEMFVNFCE DTIFEMNIAS QISEQEEEEK GEEDDEGDEG GGEGAAGGGG DEDGNGDEGR
     PESTSAFTDF LHSMSSFLSI FTFRNLRRQY RRIRKMTFKE IVVALSKFFW AILMSILTFI
     YNVCKGFFMI IWQALFGGGL VEGAKNITVT EILASMPDPT QDDVHGDGPG ELGTGEEQEA
     GGITDTGESG SGEEEEEDTQ ENEGGRIPGM DAPGGLGDMG VEEPVEPPTP EGSPITKRKM
     PGEESDASQK PPEPAPVEET PPEPEKSDVE TGEKSEKVAK SKEEEKPQEP KKSAAKKEKK
     QKKHQGFQIW TELETQRNKF MNYLSRNFYN LRFLALFLAF ALNFILLFYR VSDTPPEGGE
     MEGSGLSEGS GLFEGSGLFE GCGDEAEGSG ADGGGEDEEE DVLLYFYLEE STGYMQPTLS
     FLAILHTVIS FICIIGYNCL KIPLVIFKRE KELARKLEFD GLYITEQPED DDIKGQWDRL
     VLNTPSFPNN YWDKFVKRKV LDKYGDIYGR ERIAELLGVD LASLDVSQQH EKKQEEPDNS
     VFAWVTSIDI KYQIWKFGVV FTDGTFLYLC WYLVMSLLGH YNNFFFACHL LDIAMGVKTL
     RTILSSVTHN GKQLMMTVGL LAVVVYLYTV VAFNFFRKFY NKSEDEDEPD MKCDDMMTCY
     LFHMYVGVRA GGGIGDEIED PAGDEYELYR VVFDITFFFF VIVILLAIIQ GLIIDAFGEL
     RDQQEQVKED METKCFICGI GSDYFDTTPH GFETHTFDEH NLANYMFFLM YLINKDETEH
     TGQESYVWKM YQERCWDFFP AGDCFRKQYE DQLS
//
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