ID M4AC74_XIPMA Unreviewed; 2686 AA.
AC M4AC74;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Teneurin-1-like {ECO:0000313|Ensembl:ENSXMAP00000012068.2};
GN Name=TENM1 {ECO:0000313|Ensembl:ENSXMAP00000012068.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012068.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012068.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012068.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSXMAT00000012084.2; ENSXMAP00000012068.2; ENSXMAG00000011925.2.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF7; TENEURIN-1; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF06484; Ten_N; 2.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 296..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..289
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 618..651
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 713..748
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1731..1758
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 21..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 641..650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 717..727
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 738..747
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2686 AA; 297160 MW; 22769E2089D99DF7 CRC64;
MEEMDSKPYQ PLSKGRHEME MSYTSSSDES EDGRTHHRSY TSRETLPDYT HELRLTLGSH
RDRQKEEEEA LCTGPAAHVH SRGYSLGVGS DVDTEPEVDP SPAHGLQHMW MRGLKSEQSS
CLTSRANSAL SLTDTEHDRK SEPDNGESEL PSSPGGQFTF RPLPPPPPPP HACTCARPAP
YTQVSLQRKT MPTRCQTGQG GQGADNSSAT DQAQLHNSWV LNSNIPLETR HFLFKQGSGS
SALLSGAGQG YPLTSGTVYS PPPRPLPRSS VTRPLFTFNK PHRCCNWKCT ALSASLLTLT
LALLLTYVIA VHLLGLTWHL RNGENQLYEN GLSSADHQQE DRGKLRPTSS KWVRGRAIDR
GEIDVGTQQS QAIPPGLFWR FHMTVHHPTY VKFNLSLSHN ALLGVYGRRN IPPTHTQFDF
VKLLDGKALP RSLTDPVSTA KTPKGLLLSG LQETGFIEYM DPGTWHLALY NDGRNLEQVL
LHSTPIDSMD GCSTDCNGNG ECVAGHCHCF AGFLGPDCAK DSCPVLCSGN GMYEKGRCVC
LPGWKGAECN VEEGQCIDPT CSNHGNCIQG ICICSPAYKG VNCEQVDCAD PQCSGHGVCV
RGECVCSAGW AGVSCDDPLP ACQEQCSGHG TYLPESDTCA CQPNWTGPDC YTELCPVPCG
SHGVCSEGQC QCEEGWIGAA CDQRACHPRC EEHGQCHDGT CICQPGWEGE HCNIDGCPGL
CSGHGRCTLE QSGWRCICQA GWSGPGCSVV METDCSDGTD NDGDGLIDCV DPDCCEQLSC
GSDPLCHGSA DPLALLQQSP LPSSAPTSTH THSFYRRIRF LLGKAATHTL PGDVPFDTSR
VAVIRGNVVL QDGSPLVGVN ITFPQHPEYG YTVSRKDGSF DLVTFGAMSV TLMFQRPPFL
PQTRTIWTPN NNFLVLDHVT MAREEAETPK CDIRSVLSPY PLVLPYPLPR YTGACVEKAP
AVPELQAVQE EASIPGAFLK LSYLSTRAAG YSSLLRILLT PPSPSSPVSP LGGLSKVHVR
ASVQGRLYQR WYPAGPGLVH KLVWNKTDVY GQEVWGLTHT TVSVGYEYES CPGVIHWERR
TALMHGFELV PSNLGGWSLD KHHALNFRSG ILHKGNGENI FLSQQPPVIS TVMGNGFYRS
VPCGPSCSGA ARDMMLFAPV ALASGPDGSL YIGDFNFIRR VHPDGYTRTI LELNTSPAHK
YYLAMDPVGE VLYVSDTSSR RVYRVRNLGQ PKDPARNLEV VAGTGEQCLP FDQSHCGEGR
KATEAALNNP RGIAVDKRGV VYFVDGTTIQ KINERGLLST VIGSNGLMST QPLSCDARMD
ISQVRLEWPT DLAINPLDNS LYILDNNIVL QVSESLQVRI VAGRPIHCQV PGIDHHLVSR
AAVRATLEAA KAIALSHLGT LFIAETDERR INRIQQVSTN GEISIISGAP TDCDCKIDPN
CDCFSGDGGY ARDARLKAPS SLAVAPNGTL YIADLGNIRI RAVNPNQPQP GPAGLVEISS
PQDQELYLFS QNGSHMYTKH LITGHYLYNF SYGTDGQLSG LTSRDGRGLQ VRRDAHGVPL
WLALPGGQVY WLSLSNSGML RKVSAQGHDL AHISYHGNTG LLSTKSDENS WTTVYEYSSE
GRVTNITLPT GEVSGFHGNL ERWSRVEVEA SNRENFVTST NLSASDTIYT FKQGENSYRV
SSDGSFLVAL ASGMELSLST EPLLPGGAGG GVSPTASRCN ISLPGDHGPS LIEWRQRKEQ
SKANYSTYER RLRAHNRNLL SIDFDQNTRV GKIYDDHRKF TLHIQYDPLG RPVVWSPSSK
YTEVNISYSA GGLLSAIHRG EWSERLEYEN DRVVSRAWVN GKIWSYTYAD RSIMLLLHSQ
RRYIFDYDQT DRLVAVTMPS MVKHALQSLL SVGYYRNIYT PPESQASFMQ DYTLDGRLRR
TQYLGTGRSV IYRYTPAARL SEVVYDSTLV TFTYDEASGT VKTIHLTHDG FISSIRYRQT
GPLTSRQIFR FSEEGLVNAR FDYSYNNFRV TSMQAVINET PLPIDLYRYV DVSGRVEQFG
KFSVIFYDLN QVITTHLMKH TKVFNSYGQV VEVQYEILKS IAYWMTIQYD SAGRITTCDI
RVGVDSNVTR YTYEYDADSQ LQSASVNERP QWRYGYDLNG NINLLSHGTS SRLTPLRYDQ
RDRITHLGEL QYSVDDDGFL RQRANDLFDY NSNGLLTRVF NRATERTVWY RYDGLGRRVA
TKNSEGEQLQ FFYADLSHPT RVSHLYNHSS NLITSLYYDL QGHLIAMELS SGEEFYVACD
SVGSPRAVFS SKGRLVKEIL YTPYGEVYQD SNPDFQLTIG FHGGLYDPFT RLVHLGRRDY
DTLAGRWTSP NHELWGELSR EPKPFNLYAF NSNCPVGKVE EVTQFTTDIG RWLQLFGFQL
HNVVPGFPKP EVSRMEQTYE LMKTQTKTQD WDSSKMVLGI QCELRRQLRS FISLERLPLV
SEPVGSACHR PSHPPPFGSR PFILGPNIRF AVSHGRVSAE VIGVASEDSR RVAAILNSAV
HLTGLSFTVH GCDTHHFLQS RPIEEDLALG LGVGGRILES GVNVSVSQMS ATVNGRTRRF
ADITLQQGPL CLCVRYGGTE EEERARVKEE ARKRAVEGAW EKERKRLDLG DVGSRSWSEA
EKQQLLSGGR VQGYDGYYSL PIEQQPELSD CPANIHFMTL SEVGGR
//
