ID M4ACU7_XIPMA Unreviewed; 880 AA.
AC M4ACU7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Neuronal PAS domain-containing protein 2-like {ECO:0000313|Ensembl:ENSXMAP00000012291.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012291.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012291.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012291.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8083.ENSXMAP00000027560; -.
DR Ensembl; ENSXMAT00000012307.2; ENSXMAP00000012291.2; ENSXMAG00000012189.2.
DR Ensembl; ENSXMAT00000035652.1; ENSXMAP00000027560.1; ENSXMAG00000012189.2.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000164304; -.
DR HOGENOM; CLU_010044_2_2_1; -.
DR OMA; NQSHSAY; -.
DR OrthoDB; 2899615at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0009648; P:photoperiodism; IEA:Ensembl.
DR CDD; cd19736; bHLH-PAS_PASD1; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR46055:SF4; CIRCADIAN CLOCK PROTEIN PASD1; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 36..88
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 111..181
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 289..336
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 26..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 541..575
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 28..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 99935 MW; CC2098B6F4CE0D4C CRC64;
MDNLSDFGGP CPSTLREWDT NSCVEDLMDE DEKDRAKRAS RNKSEKKRRD QFNVLIKELC
TMLQGQGHPR KMDKSTILQR TIDFLQKQKD ITAQNEICDV KQDWKPSFLS NEEFTQLMLE
ALDGFLVALT TDGNIIYVSD SVSSLIGHLP SDVVDQNILN FLPEREHGEV YKLLSSHMLM
TDPVAADFLD GETHIEFCCH LARGNMDPKE PPVYEYVKFV GDFKFHNHVP TSSCNGHELT
LPRSLQSSLE EQVCLIATVR LVTPQFLKDL CNVDDPCDEF TSRHSLEWKF LFLDHRASPI
IGYLPFEVLG TSGYDYYHVD DLELIAQCHK QLMQFGKGKS CYYRFLTKGQ QWIWLQTHYY
ITYHQWNSKP EFIVCTHTVV SYSEVRAERR RAFGLEELSP PEIAPSSVKA QELYLDICST
LDATRDRNSG ARSVSSHSSR KSSHTALSDS LSANSYTEAC TPSWPSASVG PEKTPARLQP
SGSKNLAQRQ NSFDLVPQMS LSLSPTCSKH STMQQQSQQQ QQQSSVYQLQ QPQLGVMNQL
KEQLEERTRI LQADIKTQQQ ELHDIKEKLH LANLQMLLQQ PIHNDFNQAQ QQQQQQQQQQ
QGPGRPSQQN QNHSSVIRQL SGQPKPAACG AHSSSPLSLR DNTSPSAQVQ QRAPRSRQSQ
SVSLPMQTNT SLTTPFYSNP MMFSQTNTRP QQDTNQRQTD NQFSHDGQLR MLLNQPMQTT
VPTSSVTSQP SQCNMGISQT LYSLEQPITS FTMQQVNCNA VLVPSPVFTS PIMIPHNTFI
THQAQSAYHS QPQASHHSVQ LQQPQQFFQM TQGLVHGGSA PAFLHTTNVP QQSTMGYIQQ
QQQPQTQQLP LAQQQQQQRQ YQHSQNQQGS VSDFRNMLTR
//
