ID M4ACZ9_XIPMA Unreviewed; 2449 AA.
AC M4ACZ9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Unconventional myosin-IXa-like {ECO:0000313|Ensembl:ENSXMAP00000012343.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000012343.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000012343.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000012343.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, growth cone
CC {ECO:0000256|ARBA:ARBA00004624}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8083.ENSXMAP00000041425; -.
DR Ensembl; ENSXMAT00000012359.2; ENSXMAP00000012343.2; ENSXMAG00000012266.2.
DR Ensembl; ENSXMAT00000036846.1; ENSXMAP00000041425.1; ENSXMAG00000012266.2.
DR eggNOG; KOG1453; Eukaryota.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000154905; -.
DR HOGENOM; CLU_000192_2_2_1; -.
DR OMA; DAMAKCI; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0098529; P:neuromuscular junction development, skeletal muscle fiber; IEA:Ensembl.
DR GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR CDD; cd20883; C1_Myosin-IXa; 1.
DR CDD; cd01385; MYSc_Myo9; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 2.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR046987; Myo9.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036023; MYSc_Myo9.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46184:SF3; UNCONVENTIONAL MYOSIN-IXA; 1.
DR PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00109; C1; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 30..131
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 167..1037
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1905..1954
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1969..2157
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 919..941
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1182..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1400..1745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2203..2258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2284..2449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1430..1444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1539..1590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1686..1703
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1720..1738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2294..2314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2344..2388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2428..2449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 260..267
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2449 AA; 278362 MW; 8788D776EE18D339 CRC64;
MSLQDGGCSY ASSANLATIT GSMRRRLEDQ EFTLRVYPGS LAEGTIYCPV AARKITTAAE
AIECLIERLR LDRTKCYVLA EVKEFGGEEW ILNPGDCPVQ RMMLWPRTAL ENRSGLGSGE
DYRFLLREKN LDGSIHYGGS LQMWLRVTEE RRRMVERGFL PQPAGNDPPS DLCALPELTE
RALLESLRAR FRQEKIYTYV GSILIVINPF QFLPIYNPKY VKLYDNHTLG KLEPHIYAVA
DVAYHAMLQR RKNQCIVISG ESGSGKTQST NFLIHHLTAL SQKGFASGVE QIILGAGPVL
EAFGNAKTAH NNNSSRFGKF IQVNYQESGT VRGAYVEKYL LEKSRLVYQE HNERNYHVFY
YLLAGASEEE RKAFHLLKPE EYHYLNQMTK RPHKLHWDNF YESELQDCFT VEGEDLKHDF
ERLQLAMEMV GFLPSTRKQI FSLLSAILHL GNIRYKKKTY RDDSIDICNP EGLPIVSELL
EVKEEMLLEA LTTRKTVTVG ERLIVPYKLA EANTVRDSMA KSLYSALFDW IVFRTNHALL
NNKDLEDSSK ILSIGVLDIF GFEDYENNSF EQFCINFANE RLQHYFNQHI FKLEQEEYRA
EGISWHNIDY SDNSGCLNLI SKKPTALFHL LDEECNFPQA SNQTLLDKFK RQHEGNSYIE
FPAVMEPAFI IRHYAGKVKY GVKDFREKNT DHMRPDIVAL LKSSKNAFIC GLMGIDPVAT
FRWAVLRAYF RAVVAFREAG RRHTHKNTGN DAAVPCPVVK TVDSFSFIHH PVHQRSLEIL
QRCKDEKYSI ARKNPRTPLS ALQGTNALNE KASWDGYGVG CNGRGSRSGC VSSSGSPALE
EEGIFLNSGS SKLLERAQGI LLRNKNCKSK PSLPKHLLDV KSLRYLSSVT LHDRITKSLL
HLHKKKKPPS ISAQFQASLT KLMETLDQSE PYFVKCIRSN AEKLPLRFND SLVLRQLRYT
GMLETVRIRQ SGYSIKHTFQ EFVRHFHVLL PRGTSPTKSG IREFFRRIHL PPAGYQVGHT
MVFLREAERQ RLQTLLHQEV LRRIVMLQRR FRAVLERRHF VSMRRAARFI QRWWRSWLFS
QSGVDSSVEE AAVVCLQSAW RGYRERRRFL QQRASAVTIQ RSWRSCRRRH CTQAAVVIQT
AWRRVRERNR FCRARSSVTQ LQAIGRGYLA RVRFKLLREQ SERLSRRPRP DTGTDVGNLE
DLVPSGLDVS VSADSSEEPD PTKTDRDDDS ERSRSTDEMS HKSRSKRESR RMRELEQAQF
SLELLKVRTT SIGGSLLEDA TPDSSLAQTD DRHQRLSPQG SLASHGSFEM LSVDEMEMEG
RPLEILRDSN HNEKPVKELR PEGPRATFYI PSEQSPANLG SPSRSVKDRK ESVSRRPVVV
LISMQKESPV EEGELLAAHT LEGASQTGPF DSSTAPSEGV GAPTHKEQPT EVFPHAKRDV
AGAEKPSKLP TQALRGENPE EPALCPPKVD VQISQKSSVS TVLPGKQERK TVRPAQEAPS
PILDTKPPKA QKKSSAQTVI VNMVEKPSST VFSPPRRKLP FSKSDKDLVN QERSLSLSMH
RDDSKSAGSR NREQVSRPGP KKKARMSRTR SDFLTRCNSE GATQSDDDDE YYIPAHSCTL
PLSLSPSRAH PNTDCHSDSE MSHKEQKKIH KTMSSGDLGK VEILRKSSNQ DGSRMRGKMR
FWSKTKHSEK KLSREKQTSR SEAGETHESA SPPRSPDLEV VPSRETRDTK ENKEPSPKMK
RRRSLKISSI AVEPAQWQND SLHILTSAHD YRTMNEFLMK KIADLDSEDS KKDTMVDVVF
KKALKEFRIN IFNSYSTALA MDDGRSIRYK DLHALFEHIL EKTMRLEQRD WSESPVKVWV
NTFKVFLDEF MTEYKPMEGT IGRTLKRERK KSRKKETDIV EEHNGHIFKS TQYSIPTYCE
YCSSLIWMMD RACVCKLCRY ACHRKCCSKM TTKCSKKYDP ELSSRQFGVE LSRLTSDERA
VPQLVEKLIN YIEMHGLYTE GIYRKSGSTN KIKELRQGLD TDVSSVILDD YNIHVIASVL
KQWLRDLPSP LMTFELYEEF LRAMGQPDKR EVIQGVYSVI DQLSRTHLST LERLIFHLVR
ISLQEETNRM SVNALAIVFA PCILRCPDTI DPLQSVQDIS KTTACVELII NEQMSKYKAR
LKDISSLEFA ESKAKSRLTH IRRSLKPVLI AVRFMSITRS TTPNKVRVRQ SGSHIPSPPL
SPKAEGDGVG GAGGGGGGEE AAGETEINEQ QQQAMQQEER ILTEQIESLQ KEKEELTYEM
LVLEPRASDD ETPESEASIG TADSSENITM EMEGATSDPS ERGTYRSRKS EAKTRRTLRR
QPDSQDSVDS TSTASSSYQP SSSLSSIASG SPSPHYRFRS SSSGPLLTSC GLGAPLAEPE
DGQRTGKTRL RLRLSRSSPR DSSGSHQRES DFGPGPQQLV LYSNNEFMV
//