ID   M4AFB2_XIPMA            Unreviewed;       492 AA.
AC   M4AFB2;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase {ECO:0000313|Ensembl:ENSXMAP00000013156.1};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013156.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000013156.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013156.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
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DR   RefSeq; XP_005803278.1; XM_005803221.1.
DR   AlphaFoldDB; M4AFB2; -.
DR   STRING; 8083.ENSXMAP00000013156; -.
DR   Ensembl; ENSXMAT00000013172.2; ENSXMAP00000013156.1; ENSXMAG00000013119.2.
DR   GeneID; 102225456; -.
DR   KEGG; xma:102225456; -.
DR   CTD; 56052; -.
DR   eggNOG; KOG2941; Eukaryota.
DR   GeneTree; ENSGT00390000008647; -.
DR   HOGENOM; CLU_012079_0_0_1; -.
DR   InParanoid; M4AFB2; -.
DR   OMA; CKLIIDW; -.
DR   OrthoDB; 1219598at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000030; F:mannosyltransferase activity; IEA:InterPro.
DR   CDD; cd03816; GT33_ALG1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR   InterPro; IPR026051; ALG1-like.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   PANTHER; PTHR13036; BETA1,4 MANNOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR13036:SF0; CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   4: Predicted;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..492
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004048027"
FT   DOMAIN          340..453
FT                   /note="Glycosyl transferase family 1"
FT                   /evidence="ECO:0000259|Pfam:PF00534"
SQ   SEQUENCE   492 AA;  54444 MW;  92FA2BBA651AF01A CRC64;
     MAPCGSTVAL LSVFSAVFAV FVSCCVADSG VTCPAVCLAV AAGILSMCWR RLRQRDAASD
     RRVCVLVLGD IGRSPRMQYH ALSLSKHRYQ VTFVGFLDSK PHQDVLKQEK IQIVGISEVK
     GLRVGPKLLT YVTKTMVQAV QLLHVLLSME LQAHILMQNP PGLPGIAVAW LVCVLRGSTF
     IIDWHNYGYT IMALSLGASH PLVRLAKRYE HLFGPLASHS LCVTNAMKDD LKKNWGVEAT
     TLYDRPASIF RETPLDLQHQ LFLKMADTQP QFRASGSDSR ETEATVFTFR NLGDGGVTLR
     SDRPALLISS TSWTEDEDFS ILLDSLQEYE GFIAGGAPLP SLVCVITGKG PQKEHYRKLI
     SSLRLERVKI CTPWLEAEDY PLLLGSADLG VCLHKSSSGL DLPMKVVDMF GCCLPVCAVH
     FHCLQELVEH EVNGLIFRNS AELAQQLKSL LSEFPSSDGR LGVFRRNLRA SRGQRWDDNW
     DQNVLPLLAA PR
//