ID M4AG52_XIPMA Unreviewed; 772 AA.
AC M4AG52;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSXMAP00000013446.1};
GN Name=ARHGEF6 {ECO:0000313|Ensembl:ENSXMAP00000013446.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013446.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000013446.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013446.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR RefSeq; XP_005799618.1; XM_005799561.2.
DR AlphaFoldDB; M4AG52; -.
DR STRING; 8083.ENSXMAP00000013446; -.
DR Ensembl; ENSXMAT00000013462.2; ENSXMAP00000013446.1; ENSXMAG00000013408.2.
DR GeneID; 102224311; -.
DR KEGG; xma:102224311; -.
DR CTD; 9459; -.
DR eggNOG; KOG2070; Eukaryota.
DR GeneTree; ENSGT00940000158723; -.
DR HOGENOM; CLU_017010_1_1_1; -.
DR InParanoid; M4AG52; -.
DR OMA; ITGNMVE; -.
DR OrthoDB; 2879064at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 159..218
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 234..414
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 442..542
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 117..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 737..764
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 117..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 86167 MW; 9EB552E655C2AF5E CRC64;
MNPEEQTVTW LISLGVLSSP KKNIADPEEF LKTSLKDGVV LCKLTERLIP GFTPKYSQDP
RTEADCISNI KEFLRGCSSL KVEGFEPEWL YTGENFGKVL NTLLAFNFAT QDCAVERCPQ
SGSSSPNQTT SSHALSSTRS KGSLRRQSKS VEMSENGGGG QVMVKARFNF KQNNEDELSF
SKGDMIIVTR QEDGGWWEGT LNSKTGWFPS NYVREIKPCE KPLSPKGTPL TKNYFSVVVQ
DILEHEREFV KELQTVLTCY LRPLQANDKL SSGDSATLCG NLEEILTFQQ GLCLALEDCT
KVAEGQQRVA GCYLNLMSQI KSLYLTYCSS HPSAVCILTD HSEELGKFIE SQGASTSGIL
TLTTSLSKPF IRLDKYPTLL QELERHVEEA HPDYADIIKA TAAFKSLVSQ CQDLRKRKNL
ELQILSEPVR GWEGDSMKSL GQVAYMSLVH VRNGASEEKE ERYLMLFPNV LVMLSASPRM
SGFIYQGKLS LTGTTVTRQV EDGENTPHAF DITGGMIDRF SVFCSSAQEL QEWLEHLQPY
TKSGSPAGTI SKTANGKPLS AVGTPTHLPH LSGPSAVSRG PLEPPKTSKP WTLSCLRPAP
PLKPSAALGY KERMSYIMKD SSKSPRPIKK FLPGNRKKDR KPSDDEFQIR KSTAALEEDA
QILRVIEAYC TGASLHQTTT AVRKECVPQV LLPEEEKIIV EEIKSNGQTV TEEKSLVDAV
YALKDEVHEL KKENKWMKQF LEEEQKSRKE LERLVRKLSK QKNDCGWEDS SH
//
