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Database: UniProt
Entry: M4AG55_XIPMA
LinkDB: M4AG55_XIPMA
Original site: M4AG55_XIPMA 
ID   M4AG55_XIPMA            Unreviewed;      1737 AA.
AC   M4AG55;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   SubName: Full=Sodium leak channel, non-selective {ECO:0000313|Ensembl:ENSXMAP00000013449};
GN   Name=NALCN {ECO:0000313|Ensembl:ENSXMAP00000013449};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013449, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000013449}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013449};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000013449}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013449};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000013449}.
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DR   EMBL; AGAJ01029674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01029675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01029676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01029677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000013449; -.
DR   Ensembl; ENSXMAT00000013465; ENSXMAP00000013449; ENSXMAG00000013393.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; M4AG55; -.
DR   OMA; MLGDSAM; -.
DR   OrthoDB; EOG091G00F9; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    298    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    384    405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    417    445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    505    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    574    598       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    880    904       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    955    973       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1016   1039       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1133   1156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1210   1230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1242   1262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1298   1315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1336   1358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1423   1447       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    330       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      383    602       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      886   1161       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1208   1457       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      797    826       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1737 AA;  200603 MW;  A67905ACC1F3063F CRC64;
     MLKRKQSSRV EAQPMTDFGP DETLADSADI FWINKPWVHS LLRACAIISV ISVCMNTPKT
     FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIIKGDN SYVKDRWCMF DGFMVFFIWV
     SLVLQVFEIA KLVDQMSPWG MLRIPRALIM IRAFRIYFRF ELPRSRITNI LKRSGEQIWS
     VSIFLLFFLL LYGILGVQMF GTFNRHCVTN NTEKHSVTWN SFAIPDTHCS PDGEGYQCPL
     GFKCVDLEDY GLTRQELGYS GFNELGTSIF TVYQAASQEG WVFLMYRAID SFPRWRSYFY
     FITLIFFLAW LVKNVFIAVI IETFAEIRVQ FQQMWGSRSS TTSTATTQMF HEDAAGGWQL
     VAVDVNKPHG RAPACLQQMM RSSVFHMFIL TMVAVDVIVA ASNYYKGENY QRHYDEFYLA
     EVAFTVLFDL EALLKIWCLG FTGYISSSLH KFESLLVVGT TLHIYPDLYH SQFTYFQVLR
     VVRLIKISPA LEDFVYKIFG PGKKLGSLVV FTASLLIVMS AISLQMFCFV EELDRFTTFP
     RAFMSMFQIL TQEGWIDVMD QTLVAVGTMW APVVAIYFIL YHLFATLILL SLFVAVILDN
     LELDEDLKKL KQLKQSEANA DTKEKLPLRL RIFEKFPNRP QMVKISKLPS DFTVPRIRES
     FMKQFIDRQQ QDTSCLFRRL PSASSSSCDH SKRSAIEDNK YIDQKLRRSI FSIRARNLLE
     KETTVNKILR ACTRQRILSG SFEGQPAKER SILSVQHHIR QERRSLRHGS TSQRISRGKS
     LETLTQDHSS TVRYRNAQRE DSEIKMIQEK KEQAEMKRKV QEEELRENHP YFDKPLFIVG
     REHRFRNFCR MIVRARFNAS KTDPITGAVK NTKYHQLYDL LGLVTYLDWV MIVVTICSCI
     SMMFESPFTR VMHVPTLQIG EYVFVIFMSI ELNLKIMADG LFFTPTAVIR DFGGVMDIFI
     YLLSLIFLCW LPADVPPESG AQLLMMLRCL RPLRIFKLVP QMRKVVREVL KGFKEIFLVS
     ILLLTLMLVF ASFGVQLFAG KLAKCNDPRI LKREDCYGIF RINVSVSRNL NLKLRAEEKK
     PGFWVPRVWA NPRNFNFDNV GNAMLALFEV LSLKGWVEVR DVIIHRVGPI HGIYIHVFVF
     LGCMIGLTLF VGVVIANFNE NKGTALLTVD QRRWEDLKSR LKIAQPLHLP PRPENGGFRA
     KMYDITQHPF FKRGIAVLVL AQSVLLSVKW DVGDDKVTFP LATMSVVFTF IFVLEVTMKL
     IAMSPAGYWQ SRRNRYDLLV TSLGVIWIVL HFSLLNAYTY MMGTCVIVFR FFTICGKHVT
     LKMLLLTVVV SMYKSFFIIV GMFLLLLCYA FAGVVLFGTV KYGENINRHA NFSTAGKAIT
     VLFRIVTGED WNKIMHDCMV QPPFCTPDKH RYWETDCGNY AGALIYFCSF YVIIAYIMLN
     LLVAIIVENF SLFYSTEEDQ LLSYNDLRHF QIIWNMVDDK REGVIPTSRV KFLLRLLRGR
     LEVDLDKDKL LFKHMCYEME RLHSGGDVTF HDVLSMLSYR SVDIRKSLQL EELLAREQLE
     YTIEEEVAKQ TIRMWLKKCL KRIRAKQHQS CSIIHSLRES QQQELSSFLN PPSIETTVPS
     EDHNANNPDN PSQPEMSGLQ QLLSPTLSDR GGYRQDSTDL GRPQRKLGQW RLPAVSQQPA
     VSSIICARFP SRTSVKSIVC KMNPGNDEAS SGSEVKKWWT RQLTVESDES GDDLIDI
//
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