ID M4AH84_XIPMA Unreviewed; 978 AA.
AC M4AH84;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Apoptosis-stimulating of p53 protein 2-like {ECO:0000313|Ensembl:ENSXMAP00000013828.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013828.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000013828.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013828.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; M4AH84; -.
DR STRING; 8083.ENSXMAP00000013828; -.
DR Ensembl; ENSXMAT00000013845.2; ENSXMAP00000013828.2; ENSXMAG00000013797.2.
DR eggNOG; KOG0515; Eukaryota.
DR GeneTree; ENSGT00940000153463; -.
DR HOGENOM; CLU_008234_0_0_1; -.
DR InParanoid; M4AH84; -.
DR OMA; FTEGDCM; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0043009; P:chordate embryonic development; IEA:Ensembl.
DR GO; GO:0003341; P:cilium movement; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047163; ASPP1/2.
DR InterPro; IPR048942; ASPP2-like_RA.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR24131; APOPTOSIS-STIMULATING OF P53 PROTEIN; 1.
DR PANTHER; PTHR24131:SF16; TUMOR PROTEIN P53 BINDING PROTEIN, 2 ISOFORM X1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF21801; ASPP2-like_RA; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 808..840
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 841..873
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 907..969
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 407..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 118..184
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 209..315
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 408..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..507
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 109099 MW; BE95C40A97476700 CRC64;
MMPMFLTVHL GSNDQRVTEV PVVPEMLCRD VVELCREPGE ADCYLAETWR GSERVVEEDE
PMLEVLQRWG QQRGEVRYIL RYQRASGHET AGCRAADQTT LERLRENGFS VIPLDMSLSE
LQDLATRQQQ QIDAQQQLLA FKEQQLCHLK LQEQHQEASG QDRLLQLQEN IRNQEAKLLR
VRALRGQVEQ KRNINSKLVE EIGQMTSLFQ RKHNELELAA AKVEELSDQL EAMRNSRFEP
PFPFHPHNSS SGLTDLYKDL QLRNKLNQEQ SARLQQQKDR LKKNNLEVVA MDQRLGELQE
RLWKKKAALQ QKENLPVALN SVNPQHEPSS RVAAVGPYIQ SASRSSSQPS AVLPCQETMV
KLAYPDGTAT LPMPSSSRKP PAIPAKPSIS VETLKDNAYI PSHGASRLGH TAQAQQKDNQ
SFGNGLSKST VPPAVPTKPK LFPFSGPPTF SKPAFWTGTF PGKKKLKDPG VMSTHSNTLP
LHSNKESPPA AAVRPYTPNP TDVPPPVFQK PQTLAASSIY SMYTQQATPG KAYQAEGQGT
LSRSKPRVFG KPVLPAGKRP QTVSSESTSL RSGLCEFETE TISTAINDDK GPDADTAECA
TPRPLSPSKL LPFASNPHRN SDADLEGLRR RLHNAPRPLK KRSSVVEPEG PAGFNIEKLL
YQKTTLAAME TIPMKNISRP EENIQSTVPD GRTIKKDEDM DEDLSSSATQ QEHFPEEMFT
WPPPPYPSCE EEEQADDTFT FQQPIPQNTD LPSKQSILRK PGSDRLEHRT SVQFSPLALL
LDSSLEGEFD LVQRVIYDVD DASMPNDEGI TALHNAVCAG HTDIVKFLVQ FGVNVNAADS
DGWTPLHCAA SCNNVQVCKF LVESGAAVFA ATYSDMQTAA DKCEEMEEGY AQCSQFLYGV
QEKMGVMNRG VVYALWSYTP ENKDELGFSE GDCLTVLKQE GEVETEWWWA RCGDHEGYIP
RNLLGLYPRI KPRQRSLA
//
