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Database: UniProt
Entry: M4AH94_XIPMA
LinkDB: M4AH94_XIPMA
Original site: M4AH94_XIPMA 
ID   M4AH94_XIPMA            Unreviewed;      2428 AA.
AC   M4AH94;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   SubName: Full=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b {ECO:0000313|Ensembl:ENSXMAP00000013838};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000013838, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000013838}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013838};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000013838}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000013838};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000013838}.
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DR   EMBL; AGAJ01009473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01009482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000013838; -.
DR   Ensembl; ENSXMAT00000013855; ENSXMAP00000013838; ENSXMAG00000013771.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; M4AH94; -.
DR   OMA; IRRQNLM; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl.
DR   GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR   GO; GO:0001966; P:thigmotaxis; IEA:Ensembl.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    226    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    339    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    486    505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    612    634       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    687    713       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1175   1193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1213   1233       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1245   1263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1307   1329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1419   1444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1500   1518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1530   1553       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1610   1639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1711   1735       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1751   1786       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      709    745       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2428 AA;  276647 MW;  347DC14E9E798119 CRC64;
     MARFGDELPN RYGGGGGGGG GGGGGAGGQG GPGRGGSRQG GPPGAQRMYK QSMAQRARTM
     ALYNPIPVRQ SCLTVNRSLF LFSEDNVVRK YAKKITEWPY CTPFEWMILT TIIANCIVLA
     LEQHLPDGDK TPLSERLEET EPYFIAIFCF ESGIKILALG FALHKGSYLR NGWNVMDFVV
     VLTGILSSVG SQLDLRTLRA VRVLRPLKLV SGIPSLQVVL KSIMKAMIPL LQIGLLLFVA
     ILMFAIIGLE FYMGKFHTTC ADPVTKEKVE DRPCGPKLPS RLCPNDSSCE SGWIGPNYGI
     TQFDNILFAI LTVFQCITME GWTDMLYYSN DVEGSMWNWM YYIPLIIIGS FFMLNLVLGV
     LSGEFAKERE RVENRSEFLK LRRQQQIERE LNGYLEWICK AEEVILAEED GTGNFDGSRR
     RPTIKTRNNK TELLNQEEGE DNIGDAVGKF KGFARSSIKS GKDGTNYSKK ERRMRFFIRK
     MVKTQAFYWT VLCLVGLNTI CVAVVHYNQP ELLSDFLFYA EFIFLGLFMS EMLIKMYGLG
     IQPYFHSSFN CFDCVVIVGS IFEVVWATIK PGTSFGISVL RALRLLRIFK VTKYWAPLRN
     LVVSLLNSMK SIVSLLFLLF LFIVVFALLG MQLFGGLFNF EEGTPPTNFD TFAAAIMTVF
     QILTGEDWNM VMYDGIESQG GVKDKGMVFS IFFIVLTLFG NYTLLNVFLA IAVDNLANAQ
     ELTKDEEEQE EAANQKTALQ KAKEVAEVSP LSAANLSIAA KEQQKNHTKP NKSVWEQRTS
     EIRRQNLMTS REALYNELEQ DDWKVSFPRK ARGDVKTHLD RPLVVNPQDN CNNNTNKTPP
     GELPLDQQYR RQDVDHRRRA AHHCHYHRHH HQKSTNSDGV DATQLMETNM GHSFSCTSLG
     NVEGNVERHG DEEKHSHQSH RGHRHRNREC REARSVSPRH GKGADGNGEA RRCRQHRRAA
     READEGRRHQ CRATEGDGEK SEEEGGQKAR RHRHCNQERC RGHRVRNAYS FAHVREHHST
     CPSLSTTRPI QQYNEDLDNF RNNSKLASAQ EHPYDLPPDH PDHPDHLNNL LNCHDADTHT
     LLHSMDSLIL TSMAKPDYTS IDMPPVYPYP STNAILQVNK NANTDQKKSE EKKEEEDEGE
     DEDNAKRMPP YSSCFIMSTT NPFRKCCHYI LTLKYFEFSI LSVIAMSSIA LAAEDPVKPD
     SPRNNVLRYF DYVFTGVFTF EMLIKMVVLG LFLHQGSYFR DLWNILDFIV VSGALVAFAF
     TGSSKGKDIS TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVLNI LIVYMLFMFI
     FAVVAVQLFK GRFFYCTDES KEFARDCRGE YLVYEKDEVK AEKREWKKYD FHYDNVAWAL
     LTLFTVSTGE GWPQVLKHSV DSTYEDQGPS PGYRMEMSIF YVVYFVVFPF FFVNIFVALI
     IITFQEQGDK MMEDYSLEKN ERACIDFAIN AKPLTRHMPK NKLSFQYRMW HFVVSPPFEY
     SIMALIALNT IVLMMKHYEA NVAYDNVLKY LNIVFTAFFF MESILKIIAF GPLNYFRDAW
     NVFDFVSVIG SITDILVTEF WDNFINLSFL RLFRAARLIK LLRQGETIRI LLWTFVQSFK
     ALPYVCLLIA MLFFIYAIIG MQLFGNIALD EEEETAINEH NNFRTFIMAL MLLFRSATGE
     AWHEIMLACL GEKKCDPESG STGKECGSTF AYTYFVSFIF LCSFLMLNLF VAVIMDNFEY
     LTRDSSILGP HHLDEYVRIW AEYDPAACGR ISYTDMYQML RHMCPPLGLG KRCPARVAYK
     RLLRMDLPVA DDNTVHFNST LMALIRTALD IKIAKGGADK HQMDAELRKE MMAIWPNLSQ
     KTLDLLVTPH KATDLTVGKI YAAMMIMEYY RQSKTKKLQA LREEQNRTPL MFQRMEPPSE
     GGGTEGQAGP GQNGLPGVQP DNINSMRPPE GGLTESQSWM TAKAQEMFQK TGNWSPDRPY
     PDDVHENRHN PQTVEMREMG RDGYSDTEPC HPVDGHGRTL SMPRLSADNQ RRRHRPRGNN
     LSTITDNSPM RRSTSSLVHG RSGRGVRLDD YSLERVVSEE GRHGGGRRHR DRSHRTSQRS
     LTRYTDADTG LGTDLSTTTQ SGDLPPKERE RDRGRTKDRR HHHHHHRHHS SMDKERYDRH
     DYPHRQPQDR HWSRSPSEGP DGRGHRQGSS SVSGSPVPST SGTSTPRRGR RQLPQTPAVP
     RPHVTYSPAV RKPLYGPPGP GRLRSPSPRH FSPPDHDRGY HHRPPSRHAS PHHGGSSSRH
     GSPRSPRHQS PHSPLHGSPR SPHRNRWSGP PPGDSLEGDG PFYERDYEYE RHHEPPAYEQ
     SLSHGNPHPH GGNPHPHPRS PRTARHGPPP APHPHPRRVP NGYRSSSPSP HRRGPPGAPH
     PHHRPPHARG PRKGLHEPYS ETDEDDWC
//
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