ID M4AJU0_XIPMA Unreviewed; 355 AA.
AC M4AJU0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Pleckstrin 2 {ECO:0000313|Ensembl:ENSXMAP00000014734.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014734.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000014734.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014734.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; M4AJU0; -.
DR STRING; 8083.ENSXMAP00000014734; -.
DR Ensembl; ENSXMAT00000014754.2; ENSXMAP00000014734.2; ENSXMAG00000014691.2.
DR eggNOG; ENOG502QYJ8; Eukaryota.
DR GeneTree; ENSGT00940000157229; -.
DR HOGENOM; CLU_067828_0_0_1; -.
DR InParanoid; M4AJU0; -.
DR OMA; ITKNDIH; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037370; Pleckstrin.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12092; PLECKSTRIN; 1.
DR PANTHER; PTHR12092:SF2; PLECKSTRIN-2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 4..105
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 141..227
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 249..355
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 355 AA; 40204 MW; 92BD1BF73217C2E1 CRC64;
LGTSSFKKVF IMYIQGHIVH NWKARWFVLT PDKLLYYKYE GGKRDSCQRG KILLKDCLIT
CPFLEYENRP LAFKLQTKHG VDHFLEACSR EERDEWAADI AAAVNKLQAT DGGKLMSQKD
SAESRLQNIN LSKVLDSMYD VHSGIKLSNH VEQGSTYSNC FSGSAVVDWL VFMQLSLTRG
EAVTLASALL EEGFLRTVGL RSVEALRTAS LSEQFMDDST ALYSFPDSFK KRGSVKSERS
RSALELSGKV VKRGYLLKQG HRRKNWKVRL FVLRSEPDFL HYYDPTKDDI SPVGGFSLRG
CLISSLDDNG VPSGVKGNIQ GNLFKIITKS DIHYFIQAPT HQEKMDWIDA IREHT
//
