ID M4AJZ7_XIPMA Unreviewed; 1701 AA.
AC M4AJZ7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Rho guanine nucleotide exchange factor 28 {ECO:0000313|Ensembl:ENSXMAP00000014791.2};
GN Name=ARHGEF28 {ECO:0000313|Ensembl:ENSXMAP00000014791.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014791.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000014791.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014791.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSXMAT00000014811.2; ENSXMAP00000014791.2; ENSXMAG00000014765.2.
DR eggNOG; KOG3520; Eukaryota.
DR GeneTree; ENSGT00940000155831; -.
DR HOGENOM; CLU_002466_2_1_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR CDD; cd20876; C1_p190RhoGEF; 1.
DR CDD; cd14680; PH_p190RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037819; ARHGEF28_PH.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF22; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 679..726
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 875..1072
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1112..1214
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 510..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1342..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1436..1540
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 524..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1701 AA; 191501 MW; 6780E75F4D08B8FD CRC64;
MEVNRQEVPL YGQVDGCMLL QEAVPEDGEF YVVAEGSRLT HVATAKRGGD ERTLCFTVPG
HDRVEVVSVT AYISTNNGVY PYGCTAFLQY FRDTAQDAAE YLRGDWDQLD PQSHREVLRR
FPLLAQAADQ EICGLLEFRE VETQLRGSSG DNVDLKHLDE KITLALANME YPQQWKNPDR
EQGEGHEHHH KEALFHLAVR LHLVHLTRFL IHQTAGETLP SLPNEEGETP LQLAQGDGFD
STFSLSEAPV GPPPGVFCLW ADSSCMLRFC PGTESVSLTL RQAPVGCPQD AIMVLREKLE
DHRICRQINS VRGKHKKCHK NEAHLNDQSG TKELHVDGKQ MVDNVFYDPT TLFLIDTDGE
EENSSSLPVN GHPRRDREVQ NQFSQRTSDP LLSIVNHSDH TQQTQACEEL KIDDVTRDST
GTDGGLWDPD DLLVTDTPPP HPRCEDLLPG SVSLSPVNRA LTSVSRRPFT EPISPPLETC
DISLVALEVD SEDEGPGPKS LLSRLFSDVG RSEDKKETPP PAPDLTCTRS QSASACEPIS
KDLSEDGVRL RSYSYSYSKF CPSRNPRDSH TPEGSPDGVL HSVSHSRSLL QALSLSKSTL
SLSLLHPGKQ RASSISEQSN DKRIEEEELE KCNIPTKAES EKYKVIRTFS FLKNRMSSTR
NKNKGKGKDR EAKDRHLNGH WFGTGPCLGP TLCVVCDKPA SGKDLLHCSG CTAIVHKSCK
ESVPPCLKKL QDRCAMTVEK SKTASLPQNF TVRDSPSHSV IPISASQPVL TPRERKDTGT
QSCSLPGSLP NSDSMLSESS ETESEALRLK SHSEELLPTP GSSASNESSF GDDCVDSYIQ
THGNILADSA DYEAESWSLT VEHKFCKRQD KRAVKRQDVI YELMQTELHH LQTLHIMAEV
FRRGMKEEVQ LDTESVERVF PCLDQLLAFH HAFFAAMKER RQSSGQPPSH GNYLIQQIGD
ILLRQFSGEN GEKMKQVYGE FCSHHNEAVA FFKDLMQHNK RFQSFIKQQG HNSLVRRREI
PECILLVTQR ITKYPVLLER ILHYTQEQTE EHGNLSKALT HIRDAIAGVD VRVSEYERHQ
RLQEVWNRME NRSAAKLKSG NTFRKQDMMG QTLRHQGMLL WKTATSRLKD VLALLLTDVL
VFLQEKDQKY TFATVDQKPP VIALQKLIVR EVANEEKGMF LISASSAGPE MYEVHTSSKE
ERNTWMRLIR EAVESCPEEP EEYASESEEE KRTAEARFQK ILKLQESLTS QDQQICSSLE
EKLQIYTELS ALSERTDAAL LEPRLLVQPQ SEELPQAAAL LAAALQEAEN LKAALSSKAR
SLWSHSQDSD SVFPISPAAL SELSSEPSEE NGGNQSDGFD LQPTSDSQKN HQSIVDVEAA
EGVQTLTQLL YSLQAAVTIQ DTWYEVQKLL LQASELASPR GPCLHLHGLR GNSLQEQEKQ
RNLEKRKEEV AAAQRLREQL RQERERWERE CQAKESQQVE QESQLVERER KCLQAAQKLR
QEREELEEQL EEYQQSLERL REGQRSVERE RERLEDQQKL LQAWTHGRQS SLPAVIPHMV
IPLDVQQASP PNNSRQHSGN GSVFVNEAAF AGGSVNNRHF HHKRNDPRAH NCFNSLLDRS
NNRQYPGVTS PHGTGYIYTN PLGSPKHSTG EHSYNGNTWM STADPDPELP HPSEHHLELS
TLVSLETDSN QEEGRETIVF L
//
