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Database: UniProt
Entry: M4AKI9_XIPMA
LinkDB: M4AKI9_XIPMA
Original site: M4AKI9_XIPMA 
ID   M4AKI9_XIPMA            Unreviewed;       521 AA.
AC   M4AKI9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide-gated potassium channel 3 {ECO:0000313|Ensembl:ENSXMAP00000014983};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000014983, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000014983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014983};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000014983}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000014983};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000014983}.
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DR   EMBL; AGAJ01003104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000014983; -.
DR   Ensembl; ENSXMAT00000015003; ENSXMAP00000014983; ENSXMAG00000014968.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   OMA; ITFFEDQ; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR030173; HCN4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF375; PTHR10217:SF375; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM     56     80       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     86    107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    287    306       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      390    505       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   521 AA;  60931 MW;  9C6AF49DF8A84AA4 CRC64;
     QDQSTYFQKQ FGSMLQPGVN KFSLRMFGSH KGVAAEQERV KSFGVWIIHP YSDFRFYWDI
     VMLLLMMGNL IILPWGITFF EDQNTIPWII FNFLSDTLFL MDLVFNFRTG IPGEDSHIIL
     DPKEIRMHYL RTWFLVDFVS SIPVDYIFLI VDLESRHESS DVYRTARALR IVRFTKILSL
     LRLLRLSRLI RYIHQWEEIF HMTYDLASAV VRIVNLIGMM LLLCHWDGCL TFMVPMLQDF
     PPDCWVSKNN MVNATWHIQY SYALFMAMSH MLCIGYGAHP PEGMTDVWLT MISMVVGATC
     YAMFLGHATN LVQSLDASHR QYQEKYKQVE QYMSFHKLPA DVRQRIHDYY EHRFQGKMFD
     EDSILGELSD PLKEEIVSYN CRGLVANMPL FANTDPHFVT VILTKLRFEV FQPGDYVIRE
     GTLGRKMYFI QHGTVTIIPR GSKELMLSDG AYFGEICLLT QGRRTASVRA DTYCRLYSLS
     VDDFNEVLEE HPLMRRAFES VAVERLDRVS RRSSYQPPTT E
//
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