ID M4AL45_XIPMA Unreviewed; 390 AA.
AC M4AL45;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Tumor susceptibility 101 {ECO:0000313|Ensembl:ENSXMAP00000015189.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000015189.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000015189.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000015189.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR RefSeq; XP_005808895.1; XM_005808838.2.
DR AlphaFoldDB; M4AL45; -.
DR STRING; 8083.ENSXMAP00000015189; -.
DR Ensembl; ENSXMAT00000015209.2; ENSXMAP00000015189.1; ENSXMAG00000015140.2.
DR GeneID; 102217543; -.
DR KEGG; xma:102217543; -.
DR CTD; 415179; -.
DR eggNOG; KOG2391; Eukaryota.
DR GeneTree; ENSGT00940000153903; -.
DR HOGENOM; CLU_017548_1_1_1; -.
DR InParanoid; M4AL45; -.
DR OMA; GTVYKFP; -.
DR OrthoDB; 37962at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF17; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..146
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 322..390
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT COILED 239..311
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 390 AA; 44133 MW; 807283185FA1D9E7 CRC64;
MAVVNESALK KMLKQYKYRD LTVREITNVI SQYKDLKPVM DAYVFNDGSS RDLMSLTGTV
PVSYRGNVYN IPVCLWLLDT YPYNPPICFV KPTSTMMIKT GKHIDANGKI YLPYLHEWKH
PQSDLYGLIQ VMIVVFGEEP PVFSRPTTQP PFPSFQAAGP PNSSYMPGMP TVSPYGPNPN
AGGYPAYQYP PGNSYPATAG PGHYPTQTPV STVGPTRDGT IGEDTIRASL ISAVSDKLRW
RMKEEMDRAQ AELDALKRTE EDLKKGHQKL EEMISRLDQE VTDVDRNIEL LKKKDEELTE
ALEKMENQSE NNDIDDVIVP TAPLYKQILN LYAEENAIED TIFYLGEALR RGVIDLEVFL
KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY
//
