ID M4AL78_XIPMA Unreviewed; 1022 AA.
AC M4AL78;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Adhesion G protein-coupled receptor F5-like {ECO:0000313|Ensembl:ENSXMAP00000015222.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000015222.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000015222.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000015222.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR AlphaFoldDB; M4AL78; -.
DR Ensembl; ENSXMAT00000015243.2; ENSXMAP00000015222.1; ENSXMAG00000015197.2.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161541; -.
DR HOGENOM; CLU_011232_0_0_1; -.
DR InParanoid; M4AL78; -.
DR OMA; YQWNASV; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF10; ADHESION G PROTEIN-COUPLED RECEPTOR F5-RELATED; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1022
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004047704"
FT TRANSMEM 722..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 967..988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..227
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 720..989
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1003..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1022 AA; 113675 MW; 6AF3C7467B3EE3EA CRC64;
MWVFIFLYIL SLNSQASATE NSTQMYYAKL IIDRSAIEII SSNLSFYVKD NNVNIDNVRM
TTKCDKNNGS KTCRCEHGHK WSDEVLLKEG CDGNNCTLKA DSNSMCTLNT TVDITGRFKL
GGDNYTDCLT DKASSKYISC HARLLNQMKT LYSKIRGFDS LAIIQFSLGS IIVDFTMKIV
SDVSSGELFN KSTDLTETLT GSMTLETKGI VNLEVSKASV PYDSKTVVIC KTERELKAKP
QWNLNREDGS FLITNGSISK VEIKEKESSV TIKNVSELWQ GEYVCLFVEK EGQITINHKA
NDTMDVCLKP KIDISADPAF PLCKTEEDSV LYVIVKCEIK NTTEKYNVSW QEGAIVLPMT
TDKDKLIYSA KIIVDCKKDK GNSSPDSYCD FTNECNQVQK ASMTVEVIYP QDPYCSAEGE
WGNTKAGFTA EIKCQDKAGT RERKCSLGGK GREGIWGDEV SQCVEQDLAN VLESATISDI
GLGILATNAA IVFERFVKVT KTSKLPGYAN INTSVAVLST MDKKLNNSVI TNETAIENFL
FSSSHLLNKS LEDSWNKDTT DNTSMAEKFM LSVENLIKIS NMTGGTKKEN LHVDVCNSSN
CNITVFNVSV VLSGGVNVKT AAFKQLDKYL PNLDNKTEVN SIIVSTTADS YSDITLKFEM
IKPRPRNVEL KCVFWDNEKH AFSSDGCRWE GPSKEGHCTC DHLSSFALLL SKEPLDVPGL
TYLTYAALSV SVLSLIVTLV IELIVWSDVV KTSTLYLRHT AHVNICLCLL IGNLCFLASS
SNPENISDLW CRTSAVLKHF CYLAMFFWTF CLSATLLHQA VFLFHKVSKA NYLRFSLVVG
YAIPLIIVFV TFLTCNGGAE GVYYLEKTCW LVYGGLFKGT FYTFIIPVGA IVFINVFSML
VVIMKLISHH SEIHQKTDIS PEKEKAAAKT VVRSIILLTP IFGVTWIFGF AILIFDLTSG
PAAYAFEYIF TVLNGFQGFF ILLTTCFLDR MTREALLKHI KKKAPASSVS ESTSKSESTW
KK
//
