ID M4AMF4_XIPMA Unreviewed; 1126 AA.
AC M4AMF4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=WW and C2 domain containing 1 {ECO:0000313|Ensembl:ENSXMAP00000015648.2};
GN Name=WWC1 {ECO:0000313|Ensembl:ENSXMAP00000015648.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000015648.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000015648.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000015648.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014324740.1; XM_014469254.1.
DR AlphaFoldDB; M4AMF4; -.
DR STRING; 8083.ENSXMAP00000015648; -.
DR Ensembl; ENSXMAT00000015671.2; ENSXMAP00000015648.2; ENSXMAG00000015617.2.
DR GeneID; 102225354; -.
DR KEGG; xma:102225354; -.
DR CTD; 23286; -.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00410000025556; -.
DR HOGENOM; CLU_005420_0_0_1; -.
DR InParanoid; M4AMF4; -.
DR OMA; QVTVVSM; -.
DR OrthoDB; 1334597at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
DR GO; GO:0032475; P:otolith formation; IEA:Ensembl.
DR CDD; cd08680; C2_Kibra; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF22; PROTEIN KIBRA; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 6..39
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 53..86
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 134..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..134
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 300..327
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 367..394
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1017..1079
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 534..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..871
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..888
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1126 AA; 127023 MW; A115AD281BF27145 CRC64;
MPRKELPLPH GWEEAKDFDG KIYYINHIEQ STSWIDPRDR QTKPLTFADC IGDELPVGWE
EAYDPVVGAY YVDHNTKRTQ LEDPRAQWQR EQEAMLRDYL AVARDALSAQ KEIYQVKEQR
LQLAQQEYRQ LNDAWRDKSS SQTSLNSRSS SSSKYDPDIL KAEIATAKSR VNKLKRDLAS
MKQELQYKEQ GFETLIEINQ KVSNSPSGYK LQDAQAILNE VRSIRDAISS GEKEKQELMQ
KLAVLKDGFR LDSGSQQELW GSSPSLAISE TSIPRLYSDV GSQTDLPAEF TTSSNKLAEK
VRLSLKYDEA KRRIASIEVQ IAKLDSEAWP GLLDPERDRL ILINEKEELL KELQYISPRK
RLEPNDAEKL ETEKKRLERD LQAARDNQSK ALSERLRLHC KRSELVRELE ETVRLATSLQ
TQLRSLSAST LSCSSGSSRG SLASSRGSLA TTSSLGSASS LSFTDLYLEQ PELADPDLRS
KLDSLLQDGG PVGYRPSSSI TTIHEHEVVT GCGRRCAERS DDAGLGGAES SRVQALRLSE
TPRSMNSLSP RSSLSSLSPP CSPLVSDTTF LSGETGPGGV GLDLELRSRL AELELDPEEQ
RREQLEDQQN LNNVLGDEGK GAQTRGAGPK KMGVTSAVSD ESVAGDSGVY EPSERKPGLP
TELLLSSYED RSASGCSQVQ LGFRYESRDQ RFIVSIIQLS NCSALFMPAD QKMYVRVAVL
PPVQATRCLF RTRGLLPQDV VAINEVFGMQ TSHNGLRQKT LRVDICNTSK SGHEQCLAGA
QISLADVSCS EERCTKWYNL LSRLHMSEIN NKDKETRAQG SSGRTHEGVQ PPETDEWQGD
HLEVDMSDEE EEENDVEGME TQDEEEEFYP DNSQWVGEKE ENEEEQKVAK STPTAPITEK
VNKETSIDNL SACHQWSVVR PKERRPDFHQ QNPFMRGNTI IRSKTFSPGP QSQYICRINR
SDSDSSTLSK KSPFVRNASE RRSMRMKRPA VQVKGLDGLL RTSLDLELDL QVSRTRQTRL
TQELRVLREL KMQLEKARQQ GQRELPAWVQ EDERFRLLLK QAEKQTREEQ LQEKRVEKMM
KAAAKDVHKI RGQSQKELSE VQTFREKIAF LTRAKTSIPD LPADDV
//
