ID M4ANP8_XIPMA Unreviewed; 709 AA.
AC M4ANP8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 10 {ECO:0000313|Ensembl:ENSXMAP00000016093.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000016093.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000016093.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000016093.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MEGF family.
CC {ECO:0000256|ARBA:ARBA00038377}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; M4ANP8; -.
DR STRING; 8083.ENSXMAP00000016093; -.
DR Ensembl; ENSXMAT00000016117.2; ENSXMAP00000016093.2; ENSXMAG00000016065.2.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000157703; -.
DR HOGENOM; CLU_908985_0_0_1; -.
DR InParanoid; M4ANP8; -.
DR OMA; CECKHEA; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 3.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24052; DELTA-RELATED; 1.
DR PANTHER; PTHR24052:SF12; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1; 1.
DR Pfam; PF07546; EMI; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF00053; Laminin_EGF; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 4.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51041; EMI; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..709
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017464519"
FT TRANSMEM 555..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..104
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 146..176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 184..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 490..525
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 626..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 166..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 515..524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 709 AA; 77707 MW; 61D083DC7ABD7E50 CRC64;
MGYYIMVLST VVFWSLPYNT SSLNLDDPNV CSHWESYSRT VTESYAHRFD QIYYANCPDI
LKWFKCTTYR EMYRTAYRRG EKIMYRIKSQ CCPGFFEIGE MCAPHCEDSC VHGSCMAPNT
CRCEPGWGGS NCSSACDSDH WGPHCSNRCQ CKNGALCNPI TGSCICTPGY RGWRCEVQCE
TGSYGNGCQW TCQCQNGAIC HHVTGECNCS PGYTGTLCQD ECPVGTFGAG CAKTCHCNNS
KCVHINGTCL CDAGYTGEKC DIRLCPEDRY GLRCKKNCPC HPPRTLRYAA IDLTDFNKLY
CSFIIHRSNI KTNKNNKKSV LVDWHAVRIG CLPLASDAAK VQAGFCQLCP RGVLPSTNNA
LANLGQCHPV SGECTCQAGW SGLFCNETCT PGFYGKSCSD LCQCQNGADC HSVTGECICA
PGFMFLHSEP LFIHPIFQGS KCAVPCPAGA YGVNCSATCK CKNGVHCSPV DGSCSCTPGH
CDSVCAEGWW GPNCSLPCNC KNGTSCSPDK GTCECAPGYE GIFCQKSKDI ISGVVLFGNF
NNLTSASLHV DNYQIGVIAG IIVLVFLVLL ALPLFIIYRN KQKSKEATMP AVIYTPAIRV
TSNYTMADMV KGADYLASSS SLVSSENPYA TIKDPPSPTS KNTESSYMEM KSPTRRDSAY
AEISDTSLTN NQKVDKERFV LFHIYSYYCK MYATEWRPVQ GDPASRPDR
//