ID M4ARH7_XIPMA Unreviewed; 1248 AA.
AC M4ARH7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like {ECO:0000313|Ensembl:ENSXMAP00000017072.2};
GN Name=MAGI1 {ECO:0000313|Ensembl:ENSXMAP00000017072.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017072.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000017072.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017072.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; M4ARH7; -.
DR Ensembl; ENSXMAT00000017096.2; ENSXMAP00000017072.2; ENSXMAG00000016982.2.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00940000155820; -.
DR HOGENOM; CLU_004562_1_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 6.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF77; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF16666; MAGI_u5; 1.
DR Pfam; PF00595; PDZ; 5.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 17..100
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 104..184
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 285..318
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 345..378
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 445..514
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 614..692
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 811..893
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 972..1068
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1111..1193
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 701..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..758
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1248 AA; 136183 MW; 762EB32BA3D8679A CRC64;
MSKVIQKKNH WITKVNECAV IRDENGELNV ELHGGAENGE FAYIGQIRED AVVYQDGKLS
EGELLLEVEG LSVSGLPLYD IYTVINCCKG PVRLKTVRQG HKLNKDLKHF LSLRFQKTSP
DHELQKTIRA NLYRHAVPCT TRPPRDGEVP GLDYNFLSVE DFLQLEESGT LLEVGTYEGN
YYGTPKPPRQ PIIGTVTLSD EGSHPSTPKR TKSYHDMQKV HVVPADDDDD DQATEMNNSF
TGEGIAAPLL SLLPYITYNP SIKLVPVIGQ QTLAEPQVSP EDPLGPLPEN WEMAYTENGE
LYFIDHNTKT TSWLDPRCRD KAPRPLEECD DDECLCLMLC ALCIPELPPG WERIDDPVYG
VYYVDHINRK TQYENPVLEA RRQKILEQQQ PPQPPEEWIE EHSSAAAPLA TLCSLDPSLS
CCLLSPGGKP FFTRNPAELK GTFINTKLKK SRRGFGFTVV GGDEPDEFLQ IKSLVLDGPA
AVDGKMETGD VIVSVNDTIV LGYTHAQVVK IFQSIPIGSM VDLSLCRGYP LPFDPDDPNT
SLVTSVAILD KEPIIVNGQE TFDAPTNQAG PINGMREPRP HSPLAEVASN GSHGYSSDVV
TLASAIATQP ELITIHMEKG DKGFGFTIAD SLTGGGQRVK QIVDYPRCRG LKEGDILMEV
NKRNVQNMSH NQVVDLLSKC PRGSEVTMLV QRGMCVVPAK RSPKLQQLER KDSQSSSQHS
VCSHRSAHTD SPSHPPSAMP SEAVVPTPAA PTQPLPVLPL QDPADGTLTL QKKPDPFKIW
AQSRSMYESR REYISLSRKR KPVVPDCQEQ DIFLWRKDTG FGFRILGGNE PGEPIYIGHI
VKYGAADEDG RLRSGDELIC VDGTAVVGKS HQLVVQLMQQ AAKQGHVNLT VRRKTPGYGV
SKGEGDVPPS PASSHHSSTQ APSLTEGKRT PQGSQNSLNT VSSGSGSTSG IGSGGGGGSG
SAVIPASLQP YDVEIQRGEN EGFGFVIVSS VSRPDAGTTF AGNACVAMPH KIGRIIEGSP
ADRCGKLKVG DRILAVNGCS ITNKSHSDIV NLIKEAGNTV SLRIIPGDES SNASLLTNAE
KIATITTTHT PQTTELRYIL FLTPQDAEYY SVDLERDSKG FGFSLRGGRE YNMDLYVLRL
AEDGAAVRNG KMRVGDEILE INGESTKNMK HSRAIELIKN GGRRARLVLK RGDGSVPEYA
MMAPHLAVGT LRNDKMGEPC FYLMGQNQTT TAAVTGTLPH PGHKTLRK
//
