ID M4ASU2_XIPMA Unreviewed; 1787 AA.
AC M4ASU2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Tubulin gamma complex associated protein 6 {ECO:0000313|Ensembl:ENSXMAP00000017537.2};
GN Name=TUBGCP6 {ECO:0000313|Ensembl:ENSXMAP00000017537.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017537.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000017537.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017537.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337}.
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DR STRING; 8083.ENSXMAP00000017537; -.
DR Ensembl; ENSXMAT00000017562.2; ENSXMAP00000017537.2; ENSXMAG00000017489.2.
DR eggNOG; KOG2000; Eukaryota.
DR GeneTree; ENSGT00940000157810; -.
DR HOGENOM; CLU_002518_0_0_1; -.
DR InParanoid; M4ASU2; -.
DR OMA; VSWTEFT; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR045818; GCP6_N.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF70; GAMMA-TUBULIN COMPLEX COMPONENT 6; 1.
DR Pfam; PF19340; GCP6_N; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 42..357
FT /note="Gamma-tubulin complex component 6 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19340"
FT DOMAIN 368..689
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 1485..1784
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 271..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1264..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 701..782
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 271..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1787 AA; 198361 MW; D7265BF4BE0741BE CRC64;
MYSSSNNPTK ANSSSSITEL LSALCDRSLS GVSWKRRALG GVSREGFHRA LKKRAYGALL
SKLFQDGTKG SGSRPSAAAR TPPRNKVLMM CFDLRVAGCR EEAEALEDQL GRLREGASSG
LKEVDSVLEL LVCLAGSAPP PPTSFSRDYM RRERAVLRKP QPWSYQSEEL QRLEARAWGL
VCAEEWGTLE TLCGTQRLMD SLPRTGLLAL STKVEAEERF EKETRLSLFG ALQHTRTSDM
DIRLDLPPIP SNIDVTGLAI RVPHYLDQSE DEGFQSASNL TPDSQSEASP VPDVDIWEAV
RTFEPRRRRC WESVGCPPGN RESFYLTEGG RETFDQLYRL WEGEMRVVSS SDSSPILILP
LDSQTQLVSD LLNVLIGVAS TTFPLNQSVQ FDVRPGVCVS GASPESVSRL LGELAQYGTH
YLRLSRFCLQ SGDKKGLVFQ AFTGGLRKYL HYYRACVLST PPTLSLLTIG FLFRKVGRQL
RYLSELCCVD GLSGSGQAAF PVGVKLLSYL YNEAQSNCSN ENYPILLSLL KSCCEPYTRF
VYDWVYSGVF RDVCGEFMIQ VNEDYLSFRD KHFWVQGYTL ISMDVEDCVP VFLRQFANDV
YVCGKTINLL RICCPQHYIC WSELPVPRIA VTFSLQEVEE IERECAVYRS RMERIAKHSA
VSREEQALRA ERSRQELINQ VRESAAKTLE SIRGRQVSQR LAEEAKKRER FEELKQHLEQ
EQEWRSAAKK KQEDDDFGFA RELRDREKRL QALEEQLEQR ARKELIAQYS RLSEEAARRE
RRAMWRVQRM RLHEAREQFL MLDGQKIQVL LDKYPFGQES LPVAALPSGP SLTPQQTHEF
PTQEEQLADI RRSEAASPPL NPSAADPPPI SEDSDISDLL TKSLKPDSQQ VDNALEEIGS
DLPDAHPALQ LVDYDFSAPF SPLEGIAGQS SSQSRPRWGP AVQPELTQHS EASSSGTDQG
QNEAVPEQEA SDEQKKDQTK TEAVEADTKD QDLESGDTSG GGVSLPGPQR SLSIANIKVP
DRGSHGHSSD AHIKVGQNVS EVTAHIPSPN IHGHASDSHI KVGEHVSDVD APTPSSGAHG
HSSDAHIKIG EYVPECVLPL PVRNIHGHVS HAHIKVGEYV SEIEAPLPSP SVHGHSSDAH
IKVGENVSDV VAPRPARSVH GHSSDAHIKV GENVSDVVAP RPAPSVHGHS SDANIRVGEF
VSDVAEGRPR WSKHGHASDC VLQPGCVVSG EELPSAPLPG SSYGHSSDSA LGIGCVVQGE
EPKRAALPGS AHGHSSDSSL GIGCVVSKSD PLPSPLPGSA YGHSSDSTLG IGCVVQGSEP
PPAALPGSSY GHSSDSALGV GCVVKGKEDQ NLQKTKDKED KGSPTDDRMV CWTSGLWLSP
GEKSQQEYLM ALSAQYQVEH YEDCYNLLAS SPESQLLKQV TRGPWGLPVD PTLRRATDTT
AVQLSEMVSL PVLIKHSVTA PLITHVSLVN KAIVDYFFVE LGVERHFEAL RHFLLMEDGE
FAQSLSDLIF EKMASGQTPG ELLTPLVLNS ILSKALQYSL HGDTPLAPNF TFALRFLPET
FHPHAPDSLN CLELRYKVDW PLNIIITDSC MNKYNRLFSF LLQLKHMVWS LRDVWFHLKR
TALVKGAGRS VQFRQLQLYR HEMQHFVKVI QGYIANQILQ VSWTEFTAKL ATAGDLDGIH
RTHADYLNRA IFRGLLTEKA APVMNIIHSI FSLILKFRAQ LIAQPWDSQQ GEAVHPSFIA
MQQSYNTFKY YSHFLFKVVT KLVNRGYQPH LEDFLLRINF NNYYKDS
//
