ID   M4AT15_XIPMA            Unreviewed;       612 AA.
AC   M4AT15;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Putative all-trans-retinol 13,14-reductase {ECO:0000313|Ensembl:ENSXMAP00000017610.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017610.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000017610.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017610.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC       CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR   RefSeq; XP_005794760.1; XM_005794703.1.
DR   AlphaFoldDB; M4AT15; -.
DR   STRING; 8083.ENSXMAP00000017610; -.
DR   Ensembl; ENSXMAT00000017635.2; ENSXMAP00000017610.2; ENSXMAG00000017567.2.
DR   GeneID; 102230433; -.
DR   KEGG; xma:102230433; -.
DR   eggNOG; KOG4254; Eukaryota.
DR   GeneTree; ENSGT00940000163871; -.
DR   HOGENOM; CLU_019722_1_0_1; -.
DR   InParanoid; M4AT15; -.
DR   OMA; CMISIPS; -.
DR   OrthoDB; 36283at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR46091; BLR7054 PROTEIN; 1.
DR   PANTHER; PTHR46091:SF2; INACTIVE ALL-TRANS-RETINOL 13,14-REDUCTASE-RELATED; 1.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        569..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          72..581
FT                   /note="Amine oxidase"
FT                   /evidence="ECO:0000259|Pfam:PF01593"
SQ   SEQUENCE   612 AA;  69226 MW;  753604E2F4413FBB CRC64;
     MWLLILLVWL VIWAGGTYWY LFGKPSPFSL ESVRPPAPRE FDQKKRDKVI KQGFSVDKVP
     QNLDVIVIGS GIGGLSAAAT LAKAGKKVLV LEQHDQAGGC CHTYIEKGFE FDVGLHYIGQ
     VHENSLLRIA FDQITEGQVE FQKLQPHVDT VQIGSGVERR EYKIFTGKHE MKARLTEQFP
     NETEAIEKFF KIMKLSAKKT HYLASMKLIP QWVSLFLLKS GIADLISPVF RLSGTPATDF
     INTLTKNKDL QVIFSYFFYG VPPKESSILI NALLMHHYKR GAYYPKGGAS EIAFHIIRTI
     QKYGGSCLIR APVSQILVDE NGAAYGVKVK KGQDEVEVHA PVVVSNCGVF TTFQKLLPPE
     IQVKHDIQER LSMMKHGRGS FLIFSGFDGT AEDLGLVSTN FWLFKDNDMD KSMEDFFALS
     KEEAPDNIPM MFITVPSAKD PEANIRHPGK SCMTILTMVK YEWFEEWKDT TVRKRGDDYY
     NYKMRFTKNL FDWACTVFPK IKEKLVFQDV ATPLTNMHYL GAQRGAMYSA EHNVERFYAE
     AVARNRSSTP VKNLYISGQD VFSCGIAGAL HGGLLCASTV LNHIVYINLL ILKKKLKRKK
     ARELAQLDKK KL
//