ID M4AU91_XIPMA Unreviewed; 729 AA.
AC M4AU91;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Leucine rich repeat containing 4B {ECO:0000313|Ensembl:ENSXMAP00000018036.2};
GN Name=LRRC4B {ECO:0000313|Ensembl:ENSXMAP00000018036.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018036.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000018036.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018036.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005810181.1; XM_005810124.1.
DR AlphaFoldDB; M4AU91; -.
DR STRING; 8083.ENSXMAP00000018036; -.
DR Ensembl; ENSXMAT00000018063.2; ENSXMAP00000018036.2; ENSXMAG00000018005.2.
DR GeneID; 102232830; -.
DR KEGG; xma:102232830; -.
DR CTD; 556747; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160261; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; M4AU91; -.
DR OMA; HYNNNTT; -.
DR OrthoDB; 4239630at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF102; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4B; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..729
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017274323"
FT TRANSMEM 530..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 349..437
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 581..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 79486 MW; C149D9E6A4AD1AD7 CRC64;
MRIATLTCLS GPSPFLFLLV HLLLRLLLIL HGPQLAGAAS TCPSLCTCSN QASRVICTRQ
NLEQVPESIS VNTRYLNLQE NSIQVIKSDT FKQLRHLEIL QLSKNQIRQI EIGAFNGLPN
LNTLELFDNR LTLVPTQAFD YLSKLRELWL RNNPIETLPS YAFNRVPSLR RLDLGELKKL
EYISDAAFVG LVNLRYLNLG MCGLKDIPKL TPLVRLEELE LSGNRLDIIR PGSFQGLVSL
RKLWLMHSQV SAIERNAFDD LKNLEELNLS HNSLRSLPHD LFTPLHQLER VHLNHNPWAC
NCDVLWLSWW LKETVPSNTT CCARCHAPPL LKGKYIGELD QSHFTCFAPV IVEPPTDLNV
TEGMAAELKC RTSTSTTSVN WITPNGTLMT HGSYRVRISV LHDGTLNFTN VTLRDTGQYT
CMVTNAAGNT TATAVLNVSA ADASVNYTYF TTVTVETDNG GAHDYAQVGI EEASIPIPSD
LLPEVVPTTA SSLAGGWSAS SPRTTQPTFT VPFTEPGFSG LDDVMKTTKI IIGCFVAITF
MAAVMLVVFY KLRKQHQLHK HHGPARAIEI INVEDELGPG ASGRGSGISG GSTVTQSSGG
GIGGSQSLRL HHPEIVNLPN LARSDHLNHY YKTHHFNSNM MGLGMGTGSG VGLNNNNNPS
PCSQSQSISC SQVPSSTGGG TSTGGTLPST VALPQLGLHS SLKGLMGKGQ NEPLLFKSGS
KENVQETQI
//
