ID M4AVF6_XIPMA Unreviewed; 705 AA.
AC M4AVF6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Junctophilin-3-like {ECO:0000313|Ensembl:ENSXMAP00000018451.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018451.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000018451.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018451.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the junctophilin family.
CC {ECO:0000256|ARBA:ARBA00008599}.
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DR AlphaFoldDB; M4AVF6; -.
DR Ensembl; ENSXMAT00000018478.2; ENSXMAP00000018451.2; ENSXMAG00000018413.2.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00940000158707; -.
DR HOGENOM; CLU_008078_2_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030314; C:junctional membrane complex; IEA:InterPro.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR InterPro; IPR017191; Junctophilin.
DR InterPro; IPR003409; MORN.
DR PANTHER; PTHR23085; GH28348P; 1.
DR PANTHER; PTHR23085:SF17; JUNCTOPHILIN-3-LIKE; 1.
DR Pfam; PF02493; MORN; 8.
DR SMART; SM00698; MORN; 6.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 684..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 168..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 361..409
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 453..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 76745 MW; 0A476951EE53B179 CRC64;
MSTGGRFDFD DGGSYCGGWE QGKAHGRGVC TGPQGQGEYA GAWSHGFEVL GVYTWPSGNN
YQGTWAQGKR HGVGVESKGR WEYRGEWTQG FKGRYGQLES TASGARYEGT WSNGLQDGYG
TETYSDGGTY QGQWLAGMRH GYGVRQSVPY GMAAVILFPL RTSINSLRSE HSQGPPAALE
DGVTTTPTDG VVAGLAGSPV GRGGFALTTP SEADRQRKRK GRFRQSILSG LKLRRSESKS
SLASQLSKQS SFCSEAGMST VSSAASDIHS NASESEQGAP VDATVTEMYA GEWRSDQRAG
WGVSRRSDGL QYAGEWGANK RHGYGCTTFP DGTKEEGKYK QNVLVSGKRK NLIPLRASKI
REKVDRAVEA AEKAAEIAKQ KAEIAMSRMS HARGKAEAAE RVAQKAMEEG RLARITAKEL
SPSFHIYGNG LECQTLKHQD AKDKDHEVIS TGTDSPELCT PDTTPPVTTP DLSPVLSVPT
SPPRSPQKHV HRPRNACFMR QSAVDDQGGA EIQVLVEGRG VDLSRPSANS WTDDAYAERG
GSSRSTTPSL LEEQETQING HEQAPLSNHK PREKPSSNHN PAHSRLTERD EERMNDYTVD
MRLHCPESPA PKNNRLRSRG LRPVREGSTD SVQMLENLNV GPELEEWPLH RDLTLSPPLK
SQPITLEQEG EHLALKSNSG SSSILVVLVI LLNIGVAILF IHFFI
//