ID M4AVW5_XIPMA Unreviewed; 281 AA.
AC M4AVW5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Carbonic anhydrase 8 {ECO:0000313|Ensembl:ENSXMAP00000018610.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018610.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000018610.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018610.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718}.
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DR RefSeq; XP_005797115.1; XM_005797058.1.
DR AlphaFoldDB; M4AVW5; -.
DR STRING; 8083.ENSXMAP00000018610; -.
DR Ensembl; ENSXMAT00000018638.2; ENSXMAP00000018610.2; ENSXMAG00000018565.2.
DR GeneID; 102233994; -.
DR KEGG; xma:102233994; -.
DR CTD; 767; -.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000158863; -.
DR HOGENOM; CLU_039326_2_1_1; -.
DR InParanoid; M4AVW5; -.
DR OMA; SANGEYQ; -.
DR OrthoDB; 49814at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd03120; alpha_CARP_VIII; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR InterPro; IPR041877; CARP_VIII.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF104; CARBONIC ANHYDRASE-RELATED PROTEIN; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 18..280
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 281 AA; 31996 MW; 6D018604600A719A CRC64;
MADNVNEESD YVPGKDELDW GYEEGVEWGL HFPAANGEYQ SPINLNSREA QYDPSLLDAG
LTPNYVVCRD CEVINDGHTV HILLKSKSVV TGGPLPSDHE YELHEVRFHW GKENQRGSEH
TVNFKAFPME LHLIHWNSTL FNSLEDALGK KNGILIIALF VQIGKEHLGL KAITEVLQDL
QYKGKNKIIP CFNPNTLLPD PLLRDYWVYE GSLTTPPCSE KVTWILFRYP LTISQLQIEE
FRRLRSHIKG AELLEGNDGM LGDNFRPTQP LSDRIVRAAF Q
//
