ID M4B5Z8_HYAAE Unreviewed; 2180 AA.
AC M4B5Z8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 13-SEP-2023, entry version 42.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP801698, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP801698}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP801698};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; JH598461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblProtists; HpaT801698; HpaP801698; HpaG801698.
DR VEuPathDB; FungiDB:HpaG801698; -.
DR eggNOG; ENOG502QRBW; Eukaryota.
DR HOGENOM; CLU_231440_0_0_1; -.
DR InParanoid; M4B5Z8; -.
DR OMA; LMNRPTN; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15745; FYVE_RUFY4; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13510; FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED; 1.
DR PANTHER; PTHR13510:SF44; RABENOSYN-5; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50848; START; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 161..245
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT DOMAIN 278..337
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1639..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2022..2049
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2121..2148
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..400
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..724
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1392..1406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1407..1431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1485..1522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1595..1609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1728..1768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1802..1822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2180 AA; 241278 MW; C5B8536EF38CEED4 CRC64;
MGKARTLSRR RAASTAPGTV VTPAPSLTPN ERAYMIRKAK EASVALVEHA HTLDGPVQWH
YTGKFRGIQM YRGEGSYDHG GGSSSGTEFL CGVTTMMGSI EEVANYFNQQ TTEQMRAKKA
EDVLDCGVLY LLVRGDPKNP FYRVSAKYQL YEGPSAFSRE RDYCFLECQN TFRHASGRRG
WVLSMHSIKL PSCPEVDGVV RGSMYQSGYV FVEAEKKGYM DVMHSLQINF KSTNRLPHFL
LNSALRRRIL SVVTVSREIQ TTRMGRQTLL KKKQLMPKHS RVLCVNCARK FSLFVRKTRC
RVCGEVVCQP CAPQVTLTTK CGVVKTRVCT KCYHLSPTDD YGEEDALRDG GEDLRRMENE
TRYSDILQDH QDHPDKYRDD NKDYDDSLDD DEDEDGLEEQ SDYSVFAQSR FTDASRDSAG
TSQFGASKFD SHFKGSSQFG ATNELDDSQF NGGNTSVDSS VSGTSTSDWT GGNSAVSSVM
DWKQASSTRP ADGYIYDPQA SITSNNFYGA SSGGSSDYEA SYRTHKGKPD KRAGRYKAAV
PIPENEAHSH RGGSATSYNS STKSKSMRRS NNGAKQATMY DVSCDSHALN ESQTGKTLSI
QSLAKSRAAR YGIKSQFPPP PPPPHRNLPL DEREREVGDS PLYLGALKSD KIHSSKDRKV
HGIAARKSIA PPSPKEGRRE TDRLCARRAP KIPRGVTSNA VVASRGSQAS RASSRGSKGH
GSNRSSAIVE KVRRNRDRAT RYNSDINLSS SELKTMEKEH LARMCEIERM QELSPEKAAR
RLTAPDWSRL SVPLAQSGDR CHSNRSSAAV AGRKQKQPLR GSHRYSSHTT SNSPIQLPYA
SPPGTPPSVR SRRVPKNVFV NSRTSGSFGG NRSRQTDNSS NFEASRILSD RSNNTFAKSD
HARVSLAPSA RSEDLVFNTQ RSGLRVSKGS DSSFSDRRVD GSQGSSDISY RDRRSDTSSV
STISDIRHPG GFSLDTSQVS NDAKFSSSIA ILEPTVKSSD RIAMMESFSA ERHSLDSLLD
EDLLNQSLAG MTEHIYSMRA RAAYKLPDEE RCLSDDLQRL QEEHRKRMEE LTKMADNHII
ADIVRDSTFT FGGLHDSTSS LGGLHDSSVS LTDYSENYFG GSTMSSASST SSVDIDDETF
DFGSRPFGRS KRSGTIAFAL EEMGSVEDDD GESDDPETSY YSGQEHGEQD YRSEGESGYH
SSEKFDVRTE ENTLSTRRDS EELDTNNHED EGESIDMSHH SSRKFEEHKT RQESGFTTPP
RRISAESGER GYEQVNSLAT PLRCSTANSV ESVSERLSDP AFRPSGGVDE QSSGVITPSH
SSRVESIEST HDPNAGLCTP PRRSSVASAE SMDENTNSLA ALPRRSSVDS GGQSGHEQKS
SSAIQPHHHS VESLENGSER TDDFADSSLR CSSADSVKSE HEQSTGIATP PRRLSVESVE
SEQEQSTGIA TPPRRLSVEP VESEQEQSTG IATPPRRLSV ESVESEHEQS TGTATPPRRL
SVESVESEHV QSTGTATPPR RLSVESVESE HEQSTGTATP PRRLSVESVE SEQEQSTDIA
TPPRRLSVES AESEYEQSTG IATPPRRLSV ESVESEHEQS TGITTPLRRL SVESVESEFE
QSTGLATLPH LPRSEFVEHE HVQSTGIATP PRRLSVESVQ SEHEENTGIA TPPRRASAMS
VEHDHDYTSG LATPQRRQST EPVGSEHECA SDLVTSRRQS AQSAESEYGR DNRSDDAGSS
RSSSEENDKD LDETVTRESD HEDARPVYQS SEEPLNQQGD LEYIESAYRS SNGSIPEHAS
TTPKRMSEES VAFERRDSKF DPDSSQLILS SVVDEFSADI PNVLSDSDDS EDENNQEDTH
SPRTTPSVCS EQPQLVSTVE NGDGDHVKLS LFETLISNGT CSPDVPEHVL SSFRESCVSV
IDEELMNRPT IELFDVVRAN RSAHNMDGNR SPDTMSSLEA SHLRRMEELN QIAVDHLGNR
ISDLDEDLLG SAFRPGRSLH PGFRDEDREM QWRSSDVMEQ VHNKHEIDME KLRRRIRRLE
EECRESIASV LTAEEMDLSE FDDDDGAFNG LQSFHGHQSF SVGRSFSHQA SFTSGKSSTI
SEDGDMDTLI ETDEPLPARV LFEQIAQLTR LQQEMTEAEN DEDEEESRAR IKEQYRVLRA
IKANRRHDSG SLSEDDENWI
//
