ID M4BD11_HYAAE Unreviewed; 834 AA.
AC M4BD11;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=WW domain-containing protein {ECO:0000259|PROSITE:PS50020};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP804177, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP804177}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP804177};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NELF-D family.
CC {ECO:0000256|ARBA:ARBA00005726}.
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DR EMBL; JH598146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4BD11; -.
DR STRING; 559515.M4BD11; -.
DR EnsemblProtists; HpaT804177; HpaP804177; HpaG804177.
DR VEuPathDB; FungiDB:HpaG804177; -.
DR eggNOG; KOG0152; Eukaryota.
DR HOGENOM; CLU_014944_0_0_1; -.
DR InParanoid; M4BD11; -.
DR OMA; CHSEHTY; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR InterPro; IPR006942; TH1.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR12144:SF0; NEGATIVE ELONGATION FACTOR C_D; 1.
DR PANTHER; PTHR12144; NEGATIVE ELONGATION FACTOR D; 1.
DR Pfam; PF04858; TH1; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..32
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 58..86
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 19..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 93343 MW; 6BF1C07493F73F94 CRC64;
MPSGWSTHVT KEGRTYYYNR STKQSAWEKP ESADEDETGA SAAAAVTSST ASVAAGEWEE
LWDPKNARAY YYNRTIRKTQ WQRPEGVKIK SYTAAPAVKE KRHEKHRTHK SKKNDCEVAG
AQPDNELIDK KLLSMDAEGK ATTSGGRTNS GQSVDAGKSV EATPHLKKRK RKSKREKVEP
VAVESQQRRR RQLEERLIIC DDEEVDTDRV NDIEEKDTED GKEATRLLQE LSKTDAIMEA
NVLSVINGFL RAHTESNGPE ILVEKLSSSY RGHAQMIGLV ASWLDTLPVP TTALENKMTF
DVNEGAVVAH RGASWDPAEE ILYSHLKDVM NENYDPKLVS NVLSGSVVEP EWLTQMLNDR
KWRLMLIELA ETHKTCTLLQ YAIRRISEAG HHKEIASITS ANAFFPVFSG VLVDALSRIP
FANEEEVAED IAALNKICCQ SSHSYIYAQE LLCSMDDKLF SLQKGVSAES PEYSRIRVVR
SKLNRVRTEL QETANSRFGE KTAPFHILRR RYIYEANPKF CDAILSIIKT KKCSELSAEA
LVKEYQTSGT PPPVAHLRDP MVLSSLLDRL FNLSVLTSPA FVQKCVFLVA YAASTRDERS
LLQTEVKELS DHVEVDDAGL DLTKKALVEA SAICKSDHTL GYNMNQSGVV DKLISVMSVP
VVSMGVLHWL EVILTSPGFF SSTPLHICFP SLLRILKASI KLHVAQWPIS FSVLVTSLRL
HPENNPVKAL ELKRETLRCM VFMITSGYVL PVLEFVYTNT LELDQALLRN FISMLFARIA
PPFSPKFSAA LTKILTHPKV QTAIKLCPIE SKAKLRSFVG FCKKNPSVLS AAHF
//
