ID M4BLS3_HYAAE Unreviewed; 877 AA.
AC M4BLS3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP807358, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP807358}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP807358};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR EMBL; JH598398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4BLS3; -.
DR STRING; 559515.M4BLS3; -.
DR EnsemblProtists; HpaT807358; HpaP807358; HpaG807358.
DR VEuPathDB; FungiDB:HpaG807358; -.
DR eggNOG; KOG0731; Eukaryota.
DR HOGENOM; CLU_000688_23_1_1; -.
DR InParanoid; M4BLS3; -.
DR OMA; ARQKGNF; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.1690.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF2; SD01613P; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713}.
FT DOMAIN 401..541
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 79..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 768..795
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 112..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 95448 MW; C38073D0FBA40A5C CRC64;
MIRATTASQR LRHDRCLHLL HHRNGGRAIA RQLPQNSAVQ TRHWLQFSRP HTLLRGTKAD
KPLSWTTWLQ ENIPKGFGRF YPKNGGNGGK INGPPKSAPK AGEKGSTDIK KLSSKTSEGS
SGARKGSSGN RGGPSGKDGM AYLIPAAVAA MFLADLASTD KPMQEITYQE FRNSFLESGR
VEKLVVVNKK YVKVFLNDTP GASSSGKGSA VPGNASDMSD WRDPHAKGQH EYDFASESEY
PTNDVSGRGL NVPGMGSRGG ASGRETSNPV YYFNIGSVDG FERQIEHAQH QMGIRPHDYI
PVQYTNEISF TAEIMKFLPT IVLIGFLLMT MRGVGGGAGG GGGGIGNIFK VGKSPAKKIT
KEDIKISFKD VAGVDEAKKE IMEFVDFLRN QKRFTDLGAK IPKGALLVGP PGTGKTLLAK
ATAGEASVPF FSISGSDFIE MFVGVGPSRV RDLFKEARAN APCIVFIDEI DAVARSRSKG
NFTGGNDERE NTLNQLLVEM DGFNSSEGVV VLAGTNRADI LDKAILRPGR FDRQITVDVP
DIKGRREIFK VHLKGLTLNG AVDDFARRMA ALTPGFAGAE IANICNEAAI VAARRNGTSI
SFKDFEQATD RVIGGLETNR IMSPDEKKTV AYHEAGHAVA GWFLEHADPL LKVTIVPRGK
GSLGYAQYLP KEVALHSSEA LTDMMCMALG GRASEHVNFD GRITTGASDD LRRVTQIAYS
MVQLYGMNER VGQLSFPKDE NAYADKPYSD KTSEIMDEEV QKIVQNAYER TKQLLMEKKA
QLHELAEELL QHETINHSDI VRVLGPRPFG GNKTYTEFVE ESWKDADKYE ADKAAASKAA
SEATAEASES EGETKAASTS ESDDFKDDDD DNNEDKK
//
