ID   M4BP84_HYAAE            Unreviewed;       959 AA.
AC   M4BP84;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   22-FEB-2023, entry version 42.
DE   RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
OS   Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS   (Peronospora arabidopsidis).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Hyaloperonospora.
OX   NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP808223, ECO:0000313|Proteomes:UP000011713};
RN   [1] {ECO:0000313|Proteomes:UP000011713}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX   PubMed=21148394; DOI=10.1126/science.1195203;
RA   Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA   Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA   Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA   Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA   Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA   Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA   Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA   Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA   Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA   Tyler B.M.;
RT   "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT   arabidopsidis genome.";
RL   Science 330:1549-1551(2010).
RN   [2] {ECO:0000313|EnsemblProtists:HpaP808223}
RP   IDENTIFICATION.
RC   STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP808223};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; JH598491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M4BP84; -.
DR   EnsemblProtists; HpaT808223; HpaP808223; HpaG808223.
DR   VEuPathDB; FungiDB:HpaG808223; -.
DR   eggNOG; ENOG502SHK2; Eukaryota.
DR   HOGENOM; CLU_013242_1_0_1; -.
DR   InParanoid; M4BP84; -.
DR   OMA; YTNSDAM; -.
DR   Proteomes; UP000011713; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00065; FYVE_like_SF; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   PANTHER; PTHR43102:SF2; GAF DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43102; SLR1143 PROTEIN; 1.
DR   Pfam; PF01590; GAF; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          537..605
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          722..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   959 AA;  106918 MW;  281F00602A594854 CRC64;
     MGRQSLEIAL DEQTNQPIDQ PRSVEEALQP TDPFNQPPTP ISFDDPCIHT ASSSCTVHAE
     QRVDTLEPTL VDHGKRPSPD VHLPMRFCPV VVAPRVDSAP KKNRDTNRNN NSDEDDTDDG
     YDDREAFNEV LATRTKVRAT PLPSRQKPRR DLSTSMIANG ASSTSVAMMD PGASYDSGKS
     STTYEFTTPC SEKLLSWNGY GDSRYQRPPT IESRRDSARW SDKRVHELGL AAASKVNWDD
     LDLELATASA ASVGNQRGSS CVWKPKKFRR SGGTEMKVFS RPTVRDHRHQ TRWGPKGFAI
     LAEGSLPCTV QELRLVFRVA SSDTFRDIMR CLYRREFIDG DLLRTINLQR GSSGDPARAF
     EDRELTIKTA TFESRHRVFS KKTSLCFLEL LHPRDRAKEE QSSARRTAVS SPRLGTPPRP
     GFTRTMVSVA RPSLVLDKGR PLPSRSQLLL HVPNVIINYS FEEDPSGYGT RVVFHGEYLP
     PNAHDAFKRA GHERRHARRW ILHLAVSCQR YLLVVRRRRL GMQVMVNSTC FSAETLAASA
     SYCACCYRSF SSFLKRSRKR LCCLCGFVVC DKCAHVQERE HCARGDVRPQ IEQVRVCERC
     LLRVDQARYT AITEDDLHPA RVIPDVCAPA SRPNSTPGGR ARTDTSRHIR PNFRTRPASL
     NGLLLEILAD ATAGGPAQQQ RKESVLRVMK DIVNEDRAQR RASLARSRSL SLDASARGLL
     LQSERSGDMQ SEEENGDDDS CVGSARRRLG RMWGAAPCYE DDYPLANADS RSYRIQFPDN
     EEEAIVLPVP TNEHQRLQLI RGQQLNDLGN VPELDIICTL ASKELDCAMS MVTVVDKAKL
     HVLASSDPTI TAGESFPRAQ ALCAQTILDR NPLVACHVQA DVRFSAMSIV RRMGINFYCG
     FPLLGSDGET VIGSVCCADP QGRSLTRSQY SAMSSLASTA SRVVQRIAKQ RAVRESVKA
//