ID M4BVK0_HYAAE Unreviewed; 729 AA.
AC M4BVK0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP810544, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP810544}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP810544};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; JH597982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4BVK0; -.
DR STRING; 559515.M4BVK0; -.
DR EnsemblProtists; HpaT810544; HpaP810544; HpaG810544.
DR VEuPathDB; FungiDB:HpaG810544; -.
DR eggNOG; KOG2657; Eukaryota.
DR HOGENOM; CLU_361508_0_0_1; -.
DR InParanoid; M4BVK0; -.
DR OMA; ECVYPGV; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..729
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004049020"
FT TRANSMEM 696..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..191
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 729 AA; 77755 MW; 27D5840B863E16B3 CRC64;
MQLLPVRPPL LLPVALLLLQ WCESRASSVT AGAPDHLVTT GGECVRLFHS RGSIGCRSLS
TTDMATLYPI ASSEDLQNFI SGNSHLVASD DKYVLVMAES LVQYDVLLPR FDRIGGLFIF
PDSGATNASF DAVTPQGDGT VDGVLNPFAS DKTKWNPTGN ALLTKLLPFP VVMLQNASVG
AEFTKRAQKN ADSGSGATYK AFMNYYFGPE DMDSIKCLEF VNIYGHRSPR CDPIGGQSSW
AMRGNLKSDE IVMAMAGMDA TSLSHVLAPG ANTAASGLVA LLAAAHALKG LPDSAFDKKV
VFAAFQAEKF GFVGSRKFLS DLQQFTRDPE GACAFAVEDS VSPMGKSFCT YPMLSSTEFA
DLKLANISYA IAVDQVGILP KSGNFTLHVN PNANDSRSLV DVITSVPSAA SAVVEGNTGS
LPPTPLSSFV NDAAYGKRDL VSAVLAGYGD TFPSERTYNS RHDEFTVLDV DAVVKAAQVL
AESVFTLASS NATTAQMDKI TVDASLVRSM LLCITTDWSC DLMNDYSQYM KTTLIEYLSL
SDSASPAYSV PATLYPGPID VDGSVLVLKH SDSSMYSHFN ESWSDDDFSV RLFPNAYEFF
TRAFLASAMV PNATADAAAS CSQSQGCADG GKGMECVYPG ICATKSAFHH EASSPAIKRT
ATVLHYNVVD SSMPIWTEPQ WASDIGSYSF PDPGAIIGWV ALVVGIVVTC LGVGASFMVL
KSVQKLKLM
//
