ID M4C355_HYAAE Unreviewed; 1125 AA.
AC M4C355;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP813522, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP813522}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP813522};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH599372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4C355; -.
DR STRING; 559515.M4C355; -.
DR EnsemblProtists; HpaT813522; HpaP813522; HpaG813522.
DR VEuPathDB; FungiDB:HpaG813522; -.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_003933_0_0_1; -.
DR InParanoid; M4C355; -.
DR OMA; ALHIAMK; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24189; MYOTROPHIN; 1.
DR PANTHER; PTHR24189:SF50; MYOTROPHIN-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13676; TIR_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 368..400
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 438..470
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 537..569
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 576..608
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 609..641
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 677..709
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 732..865
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 12..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 124944 MW; 4F4E9A596D5AAC13 CRC64;
MADYHALLEA PAASSGSHNH QNNHASHRKT SSPSTEIVKT SRAPTPLLSG STDEAFMESD
SHDREAKEGA VIEGAGVITA ASRNARPRCR VWISGYGRNS YFTWRLRTSA VLVLSMAVTG
IAVFWISKDV AHGGLYVSDV SYALAFKRTK TTACIAGTDY CGACDTIVVY AMLVYHVAPL
VVLIGLPASG LRIFEPFERR QDGSGRQKLQ RSVFFQLCEL VSVLVLVFSL LVMIYFAYAL
FQGNNFFCNS GRAVLYVLCA VVTFGGNFVV LTYFARFREH LSMQLGAFKE TDQTGGIRSR
MQRRQNKHKS ERSRVVDDVR KHLYKETSLG NVSKMETLLE YAKERLGTDF AQEMYRDARL
VLKLFGRSKK NPMHMAACMG NVQALQLLLE AGFRIDSYDK VSRVRFTTGD LFWTFAQIFV
SKPLSSEDEM AASIFRTTLV TPLHCAVSTG QIQAVQWLID HGADVNLKSK ASYWSDRMPP
LFVADNPDIV VLLLEAGANH LDVPDPGHMN TLTVLQMAYM RGNFPVAHEL EKWGADVALT
PLHEAAARNN TKTVKMLLKT GADPNCVGEC GYIGMHRRTP LHWAAISGAV EAVQVLLKAG
SDSDFQDIFG RSPLHWAARV NKPDVVQVLL MNGADVNQRD YRDHTPLLCA ASSVNVSVDL
FECLVQHGAD ISDRLPNGDT ALHIAMKCEQ KGTALALLEV GADVMETNCD GYRPVDCTTS
TQLQFEIKQA AGDRDVMISY THSHSEFALK IRDSLERASI TSWLDLMDPT GIGGGSVWRE
EIARGIKNAE VIICLYTEDY AHSEWCLKEL ALAKQLGRPI IAVSTEGAAV TDEMQVYIYT
RQMVPFESAI KSVNNANKRK VTYEYDEARF AAQFRLLLDG VRDEIAKHRE AKILGSNRRL
GNGTSDVAFG ENVMDWNQAT LDNTKYVFVS HGDHHYAFVK RLRDRLQENH VGCLLDGTQM
FLDMTERIRA AKEAILKCEA FVVVLSSKTV NSELVKDQLA FAEDKGKPIL PVMLNDMEIP
LDKHYTLSRV ELLHFTPELG FNSSFMQLLS RVRDNRTPTN TSFDAPGSAT RPAFRAVAQM
TLMGSARRKN PVVVNSVARS LLGRSYLPET PVALVQPDET DATTL
//
