ID M4S017_9SPHN Unreviewed; 467 AA.
AC M4S017;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Transcriptional regulator with HTH domain protein and aminotransferase domain protein {ECO:0000313|EMBL:AGH49116.1};
GN ORFNames=G432_06955 {ECO:0000313|EMBL:AGH49116.1};
OS Sphingomonas sp. MM-1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=745310 {ECO:0000313|EMBL:AGH49116.1, ECO:0000313|Proteomes:UP000011816};
RN [1] {ECO:0000313|EMBL:AGH49116.1, ECO:0000313|Proteomes:UP000011816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM-1 {ECO:0000313|EMBL:AGH49116.1};
RX PubMed=23682148;
RA Tabata M., Ohtsubo Y., Ohhata S., Tsuda M., Nagata Y.;
RT "Complete Genome Sequence of the gamma-Hexachlorocyclohexane-Degrading
RT Bacterium Sphingomonas sp. Strain MM-1.";
RL Genome Announc. 1:E00247-13(2013).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; CP004036; AGH49116.1; -; Genomic_DNA.
DR RefSeq; WP_015458127.1; NC_020561.1.
DR AlphaFoldDB; M4S017; -.
DR STRING; 745310.G432_06955; -.
DR KEGG; sphm:G432_06955; -.
DR PATRIC; fig|745310.14.peg.1445; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_0_5; -.
DR Proteomes; UP000011816; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF2; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:AGH49116.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000011816};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:AGH49116.1}.
FT DOMAIN 10..78
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 467 AA; 50881 MW; A17BD0B95E8AB063 CRC64;
MDVSLAAPQG SLTERLAGAM RQRIASRALL PGAKLPSIRA LAASAQVSKS TVVEVYDRLA
AEGVIHSRRG SGFYVAGHLP PLSVADVGPR LDRAVDPFWV SRQSLEAGED ALKPGCGWLP
PSWLPEDILR RAMRALARAD EGALVDYGTP LGLPALRQLL SRRLAERGVE AAPDQIMLTE
SGTQAIDLLC RMLIEPGDVV LVDDPCYFNF HALLRAHRAR IVGIPFTPSG PDMDAFAEAL
AQHRPRLYVT NSGVHNPTGA TLAPAVAHRL LRLAEQHDLV IVEDDIFADF EDEPAPRLAA
LDGLDRVIQI GSFSKTLSAS VRCGYVAIRR DWLERLLDLR IATAFSAPRL STELVSRALQ
DGSYRRHVTA LRERLHRARQ RTAARLAAIG IRPWIEPRAG MFLWCRLPDG VDAADLARTA
LGQGVVLAPG NVFSLSQTAG QHMRINVAQC ADPRIFEVLK QAMHEAA
//
