ID M4U2U1_9GAMM Unreviewed; 270 AA.
AC M4U2U1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical {ECO:0000256|HAMAP-Rule:MF_00199};
DE EC=3.6.1.41 {ECO:0000256|HAMAP-Rule:MF_00199};
DE AltName: Full=Ap4A hydrolase {ECO:0000256|HAMAP-Rule:MF_00199};
DE AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase {ECO:0000256|HAMAP-Rule:MF_00199};
DE AltName: Full=Diadenosine tetraphosphatase {ECO:0000256|HAMAP-Rule:MF_00199};
GN Name=apaH {ECO:0000256|HAMAP-Rule:MF_00199,
GN ECO:0000313|EMBL:AGH80713.1};
GN ORFNames=PCNPT3_03855 {ECO:0000313|EMBL:AGH80713.1};
OS Psychromonas sp. CNPT3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Psychromonadaceae; Psychromonas.
OX NCBI_TaxID=314282 {ECO:0000313|EMBL:AGH80713.1, ECO:0000313|Proteomes:UP000010320};
RN [1] {ECO:0000313|EMBL:AGH80713.1, ECO:0000313|Proteomes:UP000010320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNPT3 {ECO:0000313|EMBL:AGH80713.1,
RC ECO:0000313|Proteomes:UP000010320};
RA Lauro F.M., Chastain R.A., Stratton T.K., Ferriera S., Johnson J.,
RA Yayanos A.A., Bartlett D.H.;
RT "The complete genome sequence of the deep-sea bacterium Psychromonas
RT CNPT2.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield
CC ADP. {ECO:0000256|ARBA:ARBA00003413, ECO:0000256|HAMAP-Rule:MF_00199}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2
CC H(+); Xref=Rhea:RHEA:24252, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58141, ChEBI:CHEBI:456216; EC=3.6.1.41;
CC Evidence={ECO:0000256|ARBA:ARBA00001682, ECO:0000256|HAMAP-
CC Rule:MF_00199};
CC -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
CC {ECO:0000256|ARBA:ARBA00005419, ECO:0000256|HAMAP-Rule:MF_00199}.
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DR EMBL; CP004404; AGH80713.1; -; Genomic_DNA.
DR RefSeq; WP_015464594.1; NC_020802.1.
DR AlphaFoldDB; M4U2U1; -.
DR STRING; 314282.PCNPT3_03855; -.
DR KEGG; psy:PCNPT3_03855; -.
DR eggNOG; COG0639; Bacteria.
DR HOGENOM; CLU_056184_2_0_6; -.
DR OrthoDB; 9807890at2; -.
DR Proteomes; UP000010320; Chromosome.
DR GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:UniProtKB-UniRule.
DR CDD; cd07422; MPP_ApaH; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_00199; ApaH; 1.
DR InterPro; IPR004617; ApaH.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR NCBIfam; TIGR00668; apaH; 1.
DR PANTHER; PTHR42850:SF11; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [SYMMETRICAL]; 1.
DR PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00199};
KW Reference proteome {ECO:0000313|Proteomes:UP000010320}.
FT DOMAIN 3..142
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 270 AA; 30635 MW; 75887E6942F5A865 CRC64;
MATYIVGDVH GCFNELKQLL VLANFNKKED ELWLTGDLVA RGPDSLSTLR FVKNLGNAAK
IILGNHDLHL LAIWQGVQSA TPQDNVDAIL NAPDCHELLD WLRKQPLLLR HPKFNFMMVH
AGILPQWSTH EAEKLATEAQ HALCADDFKH VLQTMYGNAP SKWSATLQGD ARIRFIISVF
TRMRYCYLNG SLDFKNKLPP EKNNAHELKP WYELNEHSQS NSIIFGHWAA LQGKVTKTNI
YALDTGCVWG GYLSMLRWHD KKLFSCPASI
//
