ID M5BQR3_THACB Unreviewed; 1492 AA.
AC M5BQR3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Mitochondrial Rho GTPase 1 {ECO:0000256|ARBA:ARBA00019119};
DE AltName: Full=GTPase EF-hand protein of mitochondria 1 {ECO:0000256|ARBA:ARBA00032646};
GN ORFNames=BN14_02808 {ECO:0000313|EMBL:CCO28810.1};
OS Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14) (Lettuce bottom
OS rot fungus) (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=1108050 {ECO:0000313|EMBL:CCO28810.1, ECO:0000313|Proteomes:UP000012065};
RN [1] {ECO:0000313|EMBL:CCO28810.1, ECO:0000313|Proteomes:UP000012065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG1-IB / isolate 7/3/14 {ECO:0000313|Proteomes:UP000012065};
RX PubMed=23280342; DOI=10.1016/j.jbiotec.2012.12.010;
RA Wibberg D.W., Jelonek L.J., Rupp O.R., Hennig M.H., Eikmeyer F.E.,
RA Goesmann A.G., Hartmann A.H., Borriss R.B., Grosch R.G., Puehler A.P.,
RA Schlueter A.S.;
RT "Establishment and interpretation of the genome sequence of the
RT phytopathogenic fungus Rhizoctonia solani AG1-IB isolate 7/3/14.";
RL J. Biotechnol. 0:0-0(2013).
CC -!- FUNCTION: Mitochondrial GTPase involved in mitochondrial trafficking.
CC Probably involved in control of anterograde transport of mitochondria
CC and their subcellular distribution. {ECO:0000256|ARBA:ARBA00003481}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004211}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004211}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004200}; Single-
CC pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004200}.
CC -!- SIMILARITY: Belongs to the mitochondrial Rho GTPase family.
CC {ECO:0000256|ARBA:ARBA00007981}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCO28810.1}.
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DR EMBL; CAOJ01003813; CCO28810.1; -; Genomic_DNA.
DR HOGENOM; CLU_249093_0_0_1; -.
DR Proteomes; UP000012065; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01893; Miro1; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR013566; EF_hand_assoc_1.
DR InterPro; IPR013567; EF_hand_assoc_2.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR020860; MIRO_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072:SF73; MITOCHONDRIAL RHO GTPASE; 1.
DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR Pfam; PF08355; EF_assoc_1; 1.
DR Pfam; PF08356; EF_assoc_2; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51423; MIRO; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 877..1045
FT /note="Miro"
FT /evidence="ECO:0000259|PROSITE:PS51423"
FT DOMAIN 1196..1231
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 43..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1492 AA; 163662 MW; 9DD20DA04B503670 CRC64;
MASTQVDLLS MTSIIQDRSG NSSSEHVDLG SFAPDANALR EAALKSRRKK KAVATEQLAS
IPNQQIAEAD ASQPPVRPPV DEDSSMHDAT IPVVDMPNPQ EALTETEDGE IPESKPGSET
NGIRPSEGDP REKTPRPPSS LSPRSTSIPD IAEVPGNIRQ GLDMTFRDLE EAKRLILDLL
GLGVTPEYLV DCGVSPQCLA VCFYELNLRF PLNLDRRQIN LPPLYDLDKH MKDSQRREQI
IRKRDRGRAP PRTIPPAIST IMEQTRSSHH AKALSPTPPD MEDKPLDELS PPSRLDTTPV
AGIQLPDNTQ SLPSKDLDTS LMEDQKRMEL LARKAAMESI NKKRAAKAST LSSNNSDQPG
TPYPMEISDV ESAVDALLAS VRMNSEPSNH SEGNFDKEYE GGSASTGEQL SDYDSDAMVE
DELETRSPSP SDPEVDELMD DTAFSDSQRN VSPDPIPPTP LPVSSPKLTL ARVRFDALDH
TRSSSLPAQP TPIAVPVVAR RSRPIASDFI DQAPPRPASA STAGTERSAL LKRKRSFVDP
AVWPKRIVID LDSSDDEDDQ DEAGSSGSKN NTDRTPSRAA SNDQTATNGQ DQAAQMLLEK
ELQIKAMMQK IKMRELQKKK PTSGSRTPLT GTVTPAVTTD TSKVVPSTTE LTSSPITSTM
NLTPTETPSS QAPPIIPVAA QGEYKHYVHF RLLFTFEKVE MPSLVQKGKD SVLDSSLDTV
SPKLDKGKGK ALEPEGVSQG AFSYATPALW LTSVSDNVTI SFTDESENNP RHGQLANSNS
EQAPVRTTYR YAVLVYSYFI LSDADVLELS RPWLQTHFKA YVSPLAGFTS PNLQPSSPTD
HQLSTIFWMS SSAGQDLNRQ LCTYEFPSGV CKNEICKDIH VRDFRASDGV GKSTIVTSLI
KEEYVDNVQH VVPEVTIPPE VTPENVTTYI VDSSAAPADR PHLESEIRKA HVICVVYAID
NPNSFDRVPT YWLPYFRSLG VNVPVILVGN KIDLRGGEVS NEDLENEVAP IMEEFKEVET
CVECSARIPT NIAGIIFFAQ KAVLHPTAPL YDSREHTLKP AAVDALRRIF RLCDTNKDGA
LIPFEQTCFK ASLQPQEVEG IKSILRSHDP SMLRPIPSPA HASPNGSPPP TPSVEEGVTE
DGFLYLHTEF IRRARVETTW IVLRQFGYAE DLRLTESWLS PKFEVPHDCS VELSPQGYQF
FTDIFQIFDR DQDGALRPEE LENLFNTSPG NPWAAEDDEG VDGTITLQHW LAKWSMTTLL
DHKKTLAYLA YLGYNTGPTT GALKITKPRR AERRKDKVTR NVFLCYIVGA AGSGKTSLLN
AFRQLAGGGI ETSISKDAPK SKGKGIGELG PYNPTEKVLS VVGAVELRGA EKYLVMQEFG
SKSEANMLRD PKIMNLADVI IYVHDSSDTN SFSYISGLRR HEVQPDVYCR RLGLQGPYSV
SVKNPQNLFL EIVATAINPL SAIPGGAERA SATLARRKIA LSVMGVVGGQ TG
//
