ID M5C0S0_THACB Unreviewed; 824 AA.
AC M5C0S0;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Mlh1 protein {ECO:0000313|EMBL:CCO32550.1};
GN Name=Mlh1 {ECO:0000313|EMBL:CCO32550.1};
GN ORFNames=BN14_06612 {ECO:0000313|EMBL:CCO32550.1};
OS Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14) (Lettuce bottom
OS rot fungus) (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=1108050 {ECO:0000313|EMBL:CCO32550.1, ECO:0000313|Proteomes:UP000012065};
RN [1] {ECO:0000313|EMBL:CCO32550.1, ECO:0000313|Proteomes:UP000012065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG1-IB / isolate 7/3/14 {ECO:0000313|Proteomes:UP000012065};
RX PubMed=23280342; DOI=10.1016/j.jbiotec.2012.12.010;
RA Wibberg D.W., Jelonek L.J., Rupp O.R., Hennig M.H., Eikmeyer F.E.,
RA Goesmann A.G., Hartmann A.H., Borriss R.B., Grosch R.G., Puehler A.P.,
RA Schlueter A.S.;
RT "Establishment and interpretation of the genome sequence of the
RT phytopathogenic fungus Rhizoctonia solani AG1-IB isolate 7/3/14.";
RL J. Biotechnol. 0:0-0(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCO32550.1}.
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DR EMBL; CAOJ01010030; CCO32550.1; -; Genomic_DNA.
DR AlphaFoldDB; M5C0S0; -.
DR HOGENOM; CLU_004131_2_0_1; -.
DR Proteomes; UP000012065; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 232..390
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 255..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 824 AA; 90949 MW; 615437E09C7A30C8 CRC64;
MSLVSKTLVE NTSNTESVPV IKRLDETLVN RIAAGEIIHR PSSALKELIE NALDAGATSI
KITAKDGGMK LLQIQDNGCG IRKSDLPILC ERFTTSKLRD FSDLQEIATY GFRGEALASI
SFVSHLSVVT KTRSDACAWR ALYEDGVMIA PKEGAAAEPV ACAGNDGTVI TAEDLFYNTP
VRKSSLRNQG EEYARLSDVV TRYAIHQAGV SFAGATSPDV STPVGASRSS LIRLLFGATV
AEALFDVEIS SSSVSEKATG KRKRPKGDVD TIEESWSESD EEAVPVGERD EKTKWKANAV
FTSTSYHGKK LVMLLFINHR LVESRRIQRG IEAVYSTIMP KGAHPFIYLS LEIDPKHVDV
NVHPTKREVH FLNEDVIVET ISDAIQEKLA VQSSHRTFKY QTLTPITDAN SKISFPKAST
STKASKARLA SALSDDEDEE SSRAASVTPA AKQPPKSLPQ HLVRTSLRDR TLDSMFATSS
GSSSPAQTNH KTARQLASSS ALSDDPSTTK SVGSLVKSSS KSSSSKEQTL GEGLNEDDVL
RDSIANMVMN DRDQEEDAPS IVNIPESECF LTSVLELRQQ IQDDKHSRLT DILRNSKFVG
MVDVTSTRSL FQHELKLYLV NHSAVAEELF YQLGLRQFGN FSTLKLSPPP PLHELVHLAV
NDDIDIQKAG LDPEKIGDKI IRILTNRREM LEEYFGIQIS EDGLVQSLPL LLPGYTPNID
LLPVFLMHLG PRVDWKSEKN CFDTVFREIA RFYTSKPPLD LDQGDGEQTP SEERDAAVKA
MTWQNTHIIF PAVQKYLVAP KRLIDKDVAQ IANLPDLYRV FERC
//
