ID M5C6I5_THACB Unreviewed; 612 AA.
AC M5C6I5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Choline dehydrogenase Short=CDH {ECO:0000313|EMBL:CCO35021.1};
DE EC=1.1.99.1 {ECO:0000313|EMBL:CCO35021.1};
GN ORFNames=BN14_09134 {ECO:0000313|EMBL:CCO35021.1};
OS Thanatephorus cucumeris (strain AG1-IB / isolate 7/3/14) (Lettuce bottom
OS rot fungus) (Rhizoctonia solani).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Cantharellales; Ceratobasidiaceae; Rhizoctonia; Rhizoctonia solani AG-1.
OX NCBI_TaxID=1108050 {ECO:0000313|EMBL:CCO35021.1, ECO:0000313|Proteomes:UP000012065};
RN [1] {ECO:0000313|EMBL:CCO35021.1, ECO:0000313|Proteomes:UP000012065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG1-IB / isolate 7/3/14 {ECO:0000313|Proteomes:UP000012065};
RX PubMed=23280342; DOI=10.1016/j.jbiotec.2012.12.010;
RA Wibberg D.W., Jelonek L.J., Rupp O.R., Hennig M.H., Eikmeyer F.E.,
RA Goesmann A.G., Hartmann A.H., Borriss R.B., Grosch R.G., Puehler A.P.,
RA Schlueter A.S.;
RT "Establishment and interpretation of the genome sequence of the
RT phytopathogenic fungus Rhizoctonia solani AG1-IB isolate 7/3/14.";
RL J. Biotechnol. 0:0-0(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCO35021.1}.
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DR EMBL; CAOJ01013960; CCO35021.1; -; Genomic_DNA.
DR AlphaFoldDB; M5C6I5; -.
DR HOGENOM; CLU_002865_6_0_1; -.
DR Proteomes; UP000012065; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11552:SF218; GMC_OXRDTASE_N DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:CCO35021.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 452..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..135
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 268..401
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT REGION 418..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 63897 MW; 2AD1ACC3C9B5D98A CRC64;
MKKGDLASGD TNVAAITPST LNPSNFTRSN SLAGYITPAG PRKNLVILTG MQATGLVWGS
KSNGGAVATG VNFAASAGTQ TYSVKASKEV ILCGGVIGSA QLLQVSGVGP KSLMDSLRIQ
SVVDLPGVGQ NLQDHEATSV TWSVDGATWA DLAGNATLQE EQLAEYRESS TGLWTYINEA
VAYPNIQDIM GTSAETWIST VSSQLSSALS SLSTAQSLDS TVLKGITEQF NVQLDMLRNG
VGQLEIIMTM LAGAGNVGIQ VAQQHAWSRG ELRISSASVW DYPTINPNYL SNGWDVDIMN
AGIKFVRRVG STAPMSSYLK TEGGGTSGAT TDVAINNYVA NAIATGYHPI GTCSMLPLDM
GGVVDTTLRV YGTANVRVID ASVMPIHVTA HTTAPAYAIA EYGADIVKMA YWPVPPPSSS
TTSKAGGATS TPGSSSEDDA VTGGLSQNQR TVAIAASIGG AAAVAALIAV LFFIRRRGQK
AKAQEDAYSG AYATDQRRSD LPMQTLSQSD LHAPIIPFKD GGKSDYRMSA STMDTAQLHA
ATPLQEHQHL HYDAPQSPGY AYNSQTYNPY TDVSAPGTPY MPPASGLAPG NAHEYQPVSG
RASPGSNNGP RI
//
