ID M5D755_STEMA Unreviewed; 258 AA.
AC M5D755;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Ribosomal RNA small subunit methyltransferase D {ECO:0000256|ARBA:ARBA00013682};
DE EC=2.1.1.171 {ECO:0000256|ARBA:ARBA00012141};
DE AltName: Full=16S rRNA m2G966 methyltransferase {ECO:0000256|ARBA:ARBA00031268};
DE AltName: Full=rRNA (guanine-N(2)-)-methyltransferase {ECO:0000256|ARBA:ARBA00033371};
GN ORFNames=SMRA8_1959 {ECO:0000313|EMBL:CCP16054.1};
OS Stenotrophomonas maltophilia RA8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Stenotrophomonas; Stenotrophomonas maltophilia group.
OX NCBI_TaxID=1118157 {ECO:0000313|EMBL:CCP16054.1, ECO:0000313|Proteomes:UP000012177};
RN [1] {ECO:0000313|EMBL:CCP16054.1, ECO:0000313|Proteomes:UP000012177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA8 {ECO:0000313|EMBL:CCP16054.1,
RC ECO:0000313|Proteomes:UP000012177};
RA Linke B., Adamek M., Schwartz T.;
RT "Stenotrophomonas maltophilia SKK35 and RA8 Genome sequencing: Analysis and
RT Comparison of Viurlence genes.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Specifically methylates the guanine in position 966 of 16S
CC rRNA in the assembled 30S particle. {ECO:0000256|ARBA:ARBA00002649}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) +
CC N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:23548, Rhea:RHEA-COMP:10211, Rhea:RHEA-COMP:10212,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.171;
CC Evidence={ECO:0000256|ARBA:ARBA00000252};
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RsmD family.
CC {ECO:0000256|ARBA:ARBA00005269}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCP16054.1}.
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DR EMBL; CALM01000543; CCP16054.1; -; Genomic_DNA.
DR AlphaFoldDB; M5D755; -.
DR Proteomes; UP000012177; Unassembled WGS sequence.
DR GO; GO:0052913; F:16S rRNA (guanine(966)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004398; RNA_MeTrfase_RsmD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00095; 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; 1.
DR PANTHER; PTHR43542; METHYLTRANSFERASE; 1.
DR PANTHER; PTHR43542:SF1; METHYLTRANSFERASE; 1.
DR Pfam; PF03602; Cons_hypoth95; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:CCP16054.1};
KW Transferase {ECO:0000313|EMBL:CCP16054.1}.
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 258 AA; 28287 MW; BB43B7C1BF2CE008 CRC64;
MDGATEPPWT DLRRPPQSDP PRHITGSQHL TLLRPLLRPL RVPAAGRPNY NPAHAEILEY
LPPGAPMSGR GGNDGQVRII GGRWRNTRLP VPTLPGLRPS SDRVRETLFN WLMPRLGGAR
VLDLFAGSGA LGLEAVSRGA AHATMVERDA QLGRNLTTAV AKLQATDQIT VVQSDAVRWL
QGAPAQQADL VFIDPPFADG LWQDVLAQLP RHLAADAWLY LESPAGHVPV LPPEWLLHRE
GSTREVRFAL YRRATATL
//
