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Database: UniProt
Entry: M5DL16_9GAMM
LinkDB: M5DL16_9GAMM
Original site: M5DL16_9GAMM 
ID   M5DL16_9GAMM            Unreviewed;       529 AA.
AC   M5DL16;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   05-JUL-2017, entry version 35.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CCU70450.1};
GN   ORFNames=TOL_0001 {ECO:0000313|EMBL:CCU70450.1};
OS   Thalassolituus oleivorans MIL-1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Thalassolituus.
OX   NCBI_TaxID=1298593 {ECO:0000313|EMBL:CCU70450.1, ECO:0000313|Proteomes:UP000011866};
RN   [1] {ECO:0000313|EMBL:CCU70450.1, ECO:0000313|Proteomes:UP000011866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIL-1 {ECO:0000313|EMBL:CCU70450.1};
RX   PubMed=23599290; DOI=10.1128/genomeA.00141-13;
RA   Golyshin P.N., Werner J., Chernikova T.N., Tran H., Ferrer M.,
RA   Yakimov M.M., Teeling H., Golyshina O.V.;
RT   "Genome Sequence of Thalassolituus oleivorans MIL-1 (DSM 14913T).";
RL   Genome Announc. 1:1-3(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; HF680312; CCU70450.1; -; Genomic_DNA.
DR   RefSeq; WP_015485195.1; NC_020888.1.
DR   EnsemblBacteria; CCU70450; CCU70450; TOL_0001.
DR   KEGG; tol:TOL_0001; -.
DR   PATRIC; fig|1298593.3.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000011866; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011866};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011866}.
FT   DOMAIN      226    431       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      437    506       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     234    241       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   529 AA;  58994 MW;  9A48F9147FB87AA0 CRC64;
     MTLVTGVTVT GLWQDCLGHL QHELPAQQYN TWIRPLIAST ENGQLVLSAP NRFVKDWVKD
     KYLQRIQEIL SELNGGRITH VDVTAGESRP MFSPQAAPRP EPRPAASSVE GFAFAAPRVE
     AEEPTSTFSP IASSPLKESP STNNNNEFGR QSSSNLILPG QASFNTDPMP SAPVSNKPKR
     NVQVEGGIQH QSFLNSTFTF KTFVEGKSNQ LAHAAAKQIA ENAGGSYNPL FIYGGVGLGK
     THLMHAVGNH LQSKNPNAKV LYVHSERFVQ DMVKALQLNA INEFKRFYRG LDALLIDDIQ
     FFAGKERSQE EFFHTFNALL EGGQQMILTC DRYPKEINGL EERLKSRFGW GLTVAVEPPE
     LETRVAILMK KAEQTGVNLP DDAAFFIAQK IRSNVRELEG ALKRVVANSH FTGSEITLPF
     IKESLKDLLA LQDKQVSVEN IQRTVAEYYK IKMSDLLSKR RTRSIARPRQ VAMALSKELT
     NHSLPEIGEL FGGRDHTTVL HACRKIKELQ ETSADVREDY KNLLRSLTT
//
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