ID M5ED92_MALS4 Unreviewed; 905 AA.
AC M5ED92;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Similar to S.cerevisiae protein FOX2 (3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase) {ECO:0000313|EMBL:SHO79861.1};
GN ORFNames=MSYG_4212 {ECO:0000313|EMBL:SHO79861.1};
OS Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated
OS yeast).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=1230383 {ECO:0000313|EMBL:SHO79861.1, ECO:0000313|Proteomes:UP000186303};
RN [1] {ECO:0000313|Proteomes:UP000186303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000186303};
RX PubMed=28100699; DOI=10.1093/nar/gkx006;
RA Zhu Y., Engstroem P.G., Tellgren-Roth C., Baudo C.D., Kennell J.C., Sun S.,
RA Billmyre R.B., Schroeder M.S., Andersson A., Holm T., Sigurgeirsson B.,
RA Wu G., Sankaranarayanan S.R., Siddharthan R., Sanyal K., Lundeberg J.,
RA Nystedt B., Boekhout T., Dawson T.L. Jr., Heitman J., Scheynius A.,
RA Lehtioe J.;
RT "Proteogenomics produces comprehensive and highly accurate protein-coding
RT gene annotation in a complete genome assembly of Malassezia sympodialis.";
RL Nucleic Acids Res. 45:2629-2643(2017).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; LT671827; SHO79861.1; -; Genomic_DNA.
DR RefSeq; XP_018741618.1; XM_018885016.1.
DR STRING; 1230383.M5ED92; -.
DR GeneID; 30058010; -.
DR KEGG; msym:MSY001_3125; -.
DR VEuPathDB; FungiDB:MSYG_4212; -.
DR HOGENOM; CLU_010194_18_0_1; -.
DR OMA; WATKVHT; -.
DR OrthoDB; 2140828at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000186303; Chromosome 7.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 2.
DR Gene3D; 1.10.287.4290; -; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 2.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000186303}.
SQ SEQUENCE 905 AA; 97400 MW; A7EAEC79F05637A2 CRC64;
MADFPATENG KISFKNRVVV VTGAGGGLGK TYALFFASRG AKVLVNDLGK TPEGKPAADL
VVEEITKNGG EAIANYDSNT AGAKIIQQVI DKWGRVDVLI NNAGILRDRS FKSMSDKEFD
QVLAVHVHGS FACAHAAWPY MRKQKFGRII NTSSAAGLYG NFGQANYSAA KMALVAFSKT
LGIEGEKYNI LANSIAPVAA SKMTETVMPP EMLENLKPDY VVPIVAFLCS AQNENVNGEV
FEMGAGFYAM LRRERSRGHV FRTDASFTPE AVREQMDAIL DFDESPEYPK RITDANLVEL
LERAKEAPEN KQGDGKIPYD GQTVLITGAG AGLGRAYALL FAKLGANVVV NDMSEKNALA
VVDEIKNAGG KAAPSIGSVE DGDKLVKDAL DAFGGLHTIV NNAGVLRDKS FAGASEQDWH
LVLNVHLRGT YKVCKAAWPI FLKQKYGRII NTTSAVGIYG NFGQANYSTA KSGILGLTQT
LAVEGEKYNI LANTIAPNAG TAMTATIWPQ EMVDAFKPDF VAPLVAYLGS EACEVTKGLF
EVSGGWIAAV RWERAGGCAF ATGKPVTPEM VQKKWARITD FDPERASWPS APSESLGDMV
SNFGNTEDEE EEETGDFIDP EDTDEIKAAK QAQYEATPFE YTDRDVILYN LGVGATEKDL
DLVYEQAENF QAVPTFGVIP PFAAGSSISF DSFLPNFSPM MLLHGEQYLA IKGPIPTEAK
LESRPRVIEV LDKGKAAAVT TLTTTVNAST GEPVFENQMT CFIRGSGGFG GKKTGSDRGA
ATAANKPPSR PADKVVREKT DEAQAALYRL SGDYNPLHID PNFAAVGGFD KPILHGLCSF
GIAGKHVFRA FGPYKDIKAR FTGHVFPGET LETSMWKEGN KVIFVTKVVE RNTQALGAAA
VTLDN
//
