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Database: UniProt
Entry: M5EDG7_MALS4
LinkDB: M5EDG7_MALS4
Original site: M5EDG7_MALS4 
ID   M5EDG7_MALS4            Unreviewed;       836 AA.
AC   M5EDG7;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   07-JUN-2017, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=MSY001_3376 {ECO:0000313|EMBL:CCV00670.1}, MSYG_4282
GN   {ECO:0000313|EMBL:SHO79927.1};
OS   Malassezia sympodialis (strain ATCC 42132) (Atopic eczema-associated
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=1230383 {ECO:0000313|EMBL:CCV00670.1, ECO:0000313|Proteomes:UP000016925};
RN   [1] {ECO:0000313|EMBL:CCV00670.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 42132 {ECO:0000313|EMBL:CCV00670.1};
RA   Gioti A., Nystedt B., Li W., Xu J., Andersson A., Averette A.F.,
RA   Muench K., Wang X., Kappauf C., Kingsbury J.M., Kraak B.,
RA   Johansson H., Holm T., Lehtio J., Stajich J.E., Kahmann R.,
RA   Kennell J.C., Cardenas-Corona M., Lundeberg J., Saunders C.W.,
RA   Boekhout T., Dawson T.L., Munro C., Groot P., Butler G., Heitman J.,
RA   Scheynius A.;
RT   "Genomic insights into the atopic eczema associated skin commensal
RT   yeast Malassezia sympodialis.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000016925}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42132 {ECO:0000313|Proteomes:UP000016925};
RX   PubMed=23341551; DOI=10.1128/mBio.00572-12;
RA   Gioti A., Nystedt B., Li W., Xu J., Andersson A., Averette A.F.,
RA   Muench K., Wang X., Kappauf C., Kingsbury J.M., Kraak B., Walker L.A.,
RA   Johansson H.J., Holm T., Lehtioe J., Stajich J.E., Mieczkowski P.,
RA   Kahmann R., Kennell J.C., Cardenas M.E., Lundeberg J., Saunders C.W.,
RA   Boekhout T., Dawson T.L., Munro C.A., de Groot P.W.J., Butler G.,
RA   Heitman J., Scheynius A.;
RT   "Genomic insights into the atopic eczema-associated skin commensal
RT   yeast Malassezia sympodialis.";
RL   MBio 4:E572-E572(2013).
RN   [3] {ECO:0000313|EMBL:SHO79927.1, ECO:0000313|Proteomes:UP000186303}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42132 {ECO:0000313|EMBL:SHO79927.1,
RC   ECO:0000313|Proteomes:UP000186303};
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE999574; CCV00670.1; -; Genomic_DNA.
DR   EMBL; LT671828; SHO79927.1; -; Genomic_DNA.
DR   RefSeq; XP_018741852.1; XM_018885276.1.
DR   EnsemblFungi; CCV00670; CCV00670; MSY001_3376.
DR   GeneID; 30058260; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000016925; Unassembled WGS sequence.
DR   Proteomes; UP000186303; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016925,
KW   ECO:0000313|Proteomes:UP000186303};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016925};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    422    447       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    468    485       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    540    559       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    571    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    647    667       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    768    795       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       53     80       {ECO:0000256|SAM:Coils}.
FT   COILED      103    137       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   836 AA;  94132 MW;  4F7A546DF3362E28 CRC64;
     MSDESLFRSA TMSLIQLYIP SESVHATVTE LGELGNIQFK DLNPDVAPFQ RTFVNEIRRL
     DEMDRRVQFL QEQLEREAIS VRPRESAAAF LPHEEHARGP MFMEELAKRL QEHEERVVQM
     NHSHDALQKR LLELEESKHV VRETEVFFRH AEAEPEHVRV SMDEDAHAPL LEGQGAGVRS
     LASRAPVDLE FVAGTIERSH MATLERVLWR ALRGNLYMNY AEIPAPFDDP AREEPVFKNV
     FVIFAHGAAV LAKIRKMCES MGGTLYPVES DAAQREARLH DVLERIEDHE NILYSTNAAR
     RTELVRVAES IAAWADVVRR EKLVYGTMNQ FQFDGNQKTL VAEGWVPRSD LSAVQLALRR
     ATETTGAHVS SVMQTMHTKE TPPTFQRTNK LTEGFQAIID AYGFATYQEA NPGLFTVITF
     PFLFAVMFGD LGHGVLMLLA AGAMVLYENK LLRTRLDEIT GMFFYGRYII LLMGAFAIFT
     GLMYNDVFSR SMHLFSSGWA WPRGTGTLTA QPTGRVYPVG VDPAWHGSDN NLVFTNSLKM
     KLSVVLGVAH MTFALLLNVP NHLHFKRASF IWAELVPQLL FLESLFGYLV VTIFYKWATN
     WYATDAAGAP LHNSPPGLLN MLIYMFLKPG VVEPDAQLYA GQASVQMGLL LLALVCVPWM
     LCAKPYLLWK EHQRRQGAGY HAVGSARGEQ RIHADEDDER ALAEELVDDE DEEEEFEIGE
     VVIHQIIHTI EFCLGCISNT ASYLRLWALS LAHAQLSQVL WDMTIKNVFG MTGLTGVLAT
     VFAFALWFVL TIAILCVMEG LSAFLHALRL HWVEGGSKHY EAAGYPFQPL SLAADL
//
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