ID   M5UI00_9LEPT            Unreviewed;      1139 AA.
AC   M5UI00;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=AAA ATPase domain protein {ECO:0000313|EMBL:EMI61052.1};
GN   ORFNames=LEP1GSC076_0621 {ECO:0000313|EMBL:EMI61052.1};
OS   Leptospira sp. Fiocruz LV4135.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1193013 {ECO:0000313|EMBL:EMI61052.1, ECO:0000313|Proteomes:UP000011956};
RN   [1] {ECO:0000313|EMBL:EMI61052.1, ECO:0000313|Proteomes:UP000011956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fiocruz LV4135 {ECO:0000313|EMBL:EMI61052.1,
RC   ECO:0000313|Proteomes:UP000011956};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Ko A.I., Reis M.G., Ribeiro G.S., Wunder E.Jr.,
RA   Vinetz J.M., Sutton G.G., Nierman W.C., Fouts D.E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMI61052.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AOHI01000124; EMI61052.1; -; Genomic_DNA.
DR   AlphaFoldDB; M5UI00; -.
DR   PATRIC; fig|1193013.3.peg.4112; -.
DR   Proteomes; UP000011956; Unassembled WGS sequence.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          6..138
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          694..727
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1139 AA;  129305 MW;  077E89A5F7CCACAD CRC64;
     MTNIHKAFSG DYREVASVFV RIDSPLESNT DSKNFNNFFT YVQSVATSCS GTFVLTDLSD
     KGGVFSVLFG APAALENKEA LAARFAVRLL EGASNYPAAK NLQIGISTGM AYCGDLGAPF
     RKDFTAIGEM MNIAARLATL SGHSGVLIDF QTKNKLAKSF SFHEVGDVEL KGVSGAKKIF
     QLTSEQKNIP GLLIQYRDKM IGRKEELDRL HKMLDTSSAK GGVICRIIAD AGIGKSRLTN
     TFIDQAYDRN VEILIGYCYP YEKFTPFYPW KELLSLFLGI FEDDSVETRV SKAEKALDHN
     LNSFDIAWAK ALVALMGVPV EEDPLTREID RKQKTERLFE IIISLLQKRA DEKPLALVFE
     DVHWIDELSG RLLEKLAFQL STMKVMLILV SRPEGQFAED SVSPNEELIR LKEFKPEEAR
     DFLIHKFKLD TSQEEFLDQI LNRSGGNPFF LESIVHNLIE EGTLKKLEDG TLSPSDKSRD
     IQIPNTLNDV LLARVDRLQE REKIVLKTAS VIGRLINVDT LNHLLPTEFR SEAQDILQNL
     EGLDLTPLEV TDPLTYIFKH IVIRDIVYNT LLHSTREDLH KRIASFIEKE NENNVTEMAD
     ILAFHYQQCA DFEKAYKYSL MAARKAKSKY ANRDAIYHYN KALEMIAQFE TTKGEAYYEI
     KQELAHSHRL LGEYSIAEVL FKECLENKSI LNLIRSYTGL GQVYQEQDDI SRAMETLEKA
     LRITGVRPPS SRPDTIFKIV LQLSFILRFS IFGSSYTSSN KAERLKLRCI ILTTLAKLYI
     MKDVKKFGWS VFTQYNATQR FEDPVRQSLA ECALGQVFVG MNLFGPSKYF LIRGRELAEK
     TGDPYAKAIS ILVQSAYYMM LNRPDLGLPF LHDSISIYRQ VGEKWDLLSA LSSGGFLYYL
     QSDFRTAKKY FDDIGEIASE LGAQLQLRWT RIWSPYFGYL LGEMEPLELE KKLLIEAERA
     ALENDVMNEL STINKLLKLT MLEGWPEKAA YWSKRSYAGF LKCEVKFPQL QIGNVYFAEA
     ALYAKKELGN GDKSLDKIIN YGLKHGLKLG KFLPYLYGPA LMLKGKLKLY GGNRKDAEII
     FKKAESFLSN TLNQWEYATA LYEAGLLLED KNRISVAKGI LQQLEARADL KRLEESSIV
//