ID M6D1T0_9LEPT Unreviewed; 724 AA.
AC M6D1T0;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Adenylate/guanylate cyclase catalytic domain protein {ECO:0000313|EMBL:EMJ96656.1};
GN ORFNames=LEP1GSC194_4408 {ECO:0000313|EMBL:EMJ96656.1};
OS Leptospira alstonii serovar Sichuan str. 79601.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1218565 {ECO:0000313|EMBL:EMJ96656.1, ECO:0000313|Proteomes:UP000011988};
RN [1] {ECO:0000313|EMBL:EMJ96656.1, ECO:0000313|Proteomes:UP000011988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=79601 {ECO:0000313|EMBL:EMJ96656.1,
RC ECO:0000313|Proteomes:UP000011988};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Galloway R.L., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMJ96656.1}.
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DR EMBL; ANIK01000016; EMJ96656.1; -; Genomic_DNA.
DR RefSeq; WP_020772410.1; NZ_ANIK01000016.1.
DR AlphaFoldDB; M6D1T0; -.
DR PATRIC; fig|1218565.3.peg.1037; -.
DR OrthoDB; 9806704at2; -.
DR Proteomes; UP000011988; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 458..597
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REPEAT 660..693
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 724 AA; 82724 MW; EE3423F64287B80B CRC64;
MKTILFFLCT FIPSLIFSEN QDSWKPIDLR KVNWIATDEF QKEYPNGIDP TLPTVKKIST
FPIVLNEIFE TPIGRGLKEY TLQTRFHIEG DFRNTKVYKP IFLYLESIGE NWEIFLNGHS
LAREIHLDSS GKEMFVRRTI RSFRLPVDSS LLRSGENLLT FHLIGDVPAS AFSKNVDLGF
YIDGDYSLTT EQKLSGEIST LVNLCLNTIY VFFGLYHLLI YAKRREDLYN LYFGIFSVFM
ALYSLSRSNI AFDVIHDTTW ITRIEYSSVS LLSPLFLLFM QDYFYGRAKF SKVLFGILVL
DVIIAAITLV EPFRYTMTSL RIWQISILPT LVYLLYFMSK ALYFRKKDAI LLATSMFTVV
FIAVYDVIDS VFFQSGIRFT QFAYFLFVVA LTVILANRFI SLYRQSEDLN IELSQQKLEL
ARQKNAFFRF VPVQFLNVLG KNSAVEVNLG DSVLKEMSVL FTDIRSFTTI SEQMTPEENF
RFINDYLASM EPVVQKHEGF VDKFMGDGIL ALFSGEGEAI QSRLYGKTSA DKAILAAIEM
KKAVQAINAE AKDSHFRGLR IGIGINTGNL MLGTVGSRSR LDTTVIGDTV NVASRLESLT
NLYRADILIT KNTLSCMTIA DDLAIREIDS VVVKGKTDPI IIYEVYEADV PHIRKLKDTT
LPLITRGIIL YKVADFQEAL INFEQALKVF PEDIVSILYR KRCQEYIASP PNGNWIGVQH
LLEK
//
