ID   M6DB78_9LEPT            Unreviewed;       412 AA.
AC   M6DB78;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=site-specific DNA-methyltransferase (cytosine-N(4)-specific) {ECO:0000256|ARBA:ARBA00012185};
DE            EC=2.1.1.113 {ECO:0000256|ARBA:ARBA00012185};
GN   ORFNames=LEP1GSC194_3337 {ECO:0000313|EMBL:EMJ95805.1};
OS   Leptospira alstonii serovar Sichuan str. 79601.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1218565 {ECO:0000313|EMBL:EMJ95805.1, ECO:0000313|Proteomes:UP000011988};
RN   [1] {ECO:0000313|EMBL:EMJ95805.1, ECO:0000313|Proteomes:UP000011988}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=79601 {ECO:0000313|EMBL:EMJ95805.1,
RC   ECO:0000313|Proteomes:UP000011988};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Galloway R.L., Vinetz J.M., Sutton G.G.,
RA   Nierman W.C., Fouts D.E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC         Evidence={ECO:0000256|ARBA:ARBA00001893};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC       subfamily. {ECO:0000256|ARBA:ARBA00010203}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMJ95805.1}.
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DR   EMBL; ANIK01000029; EMJ95805.1; -; Genomic_DNA.
DR   AlphaFoldDB; M6DB78; -.
DR   PATRIC; fig|1218565.3.peg.1612; -.
DR   Proteomes; UP000011988; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR002941; DNA_methylase_N4/N6.
DR   InterPro; IPR017985; MeTrfase_CN4_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF01555; N6_N4_Mtase; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR   PROSITE; PS00093; N4_MTASE; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EMJ95805.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EMJ95805.1}.
FT   DOMAIN          31..114
FT                   /note="DNA methylase N-4/N-6"
FT                   /evidence="ECO:0000259|Pfam:PF01555"
FT   DOMAIN          278..403
FT                   /note="DNA methylase N-4/N-6"
FT                   /evidence="ECO:0000259|Pfam:PF01555"
SQ   SEQUENCE   412 AA;  47561 MW;  A71859C12A623439 CRC64;
     MEREFVEFPQ DSFFSLGGNL RSIRKSFHTM STALKRKERK IQIGEFWTSR QRQSHSIHYS
     VSYRASFKPE LPAFFLDRYL SKKKGVVLDP FGGRGTTSIQ ANLEGHSAIH NDISPMSLFL
     AKSRQTIPSF DSMEKILGRL DLKKKTREEK EDRDLLAFYH KDTLNEIKNL KRILSGDSSP
     EIQYIGITAL SRLHGHSDGF FSVYSFPQIS IPPAAQKRNN EKKGIKPEYK EIKSRILQKM
     KRDLKTPLPP FYHDFSGRNR YTNHSSLFLE SLEDGVADLV VTSPPFLDKV NYEEDNWLRY
     WFLDIELPDH KKPSIFSTLS AWTDFIHGSL KELSRVLKPD GVCVMEVGDI KKGATVFNLD
     EYVIQAASQS GLEWETTFIN DQKFTKLSNC WNVSNNEKGT NSNRCVVFRN YK
//