ID M6GJ15_LEPIR Unreviewed; 790 AA.
AC M6GJ15;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Thermolysin metallopeptidase, alpha-helical domain protein {ECO:0000313|EMBL:EMM82504.1};
GN ORFNames=LEP1GSC037_1950 {ECO:0000313|EMBL:EMM82504.1};
OS Leptospira interrogans str. 2006001854.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1001590 {ECO:0000313|EMBL:EMM82504.1, ECO:0000313|Proteomes:UP000012128};
RN [1] {ECO:0000313|EMBL:EMM82504.1, ECO:0000313|Proteomes:UP000012128}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2006001854 {ECO:0000313|EMBL:EMM82504.1,
RC ECO:0000313|Proteomes:UP000012128};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Hospenthal D.R., Murray C.K., Pimentel G.,
RA Wasfy M., Parker T., Miller R.S., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMM82504.1}.
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DR EMBL; AFLW02000081; EMM82504.1; -; Genomic_DNA.
DR AlphaFoldDB; M6GJ15; -.
DR Proteomes; UP000012128; Unassembled WGS sequence.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR045474; GEVED.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF20009; GEVED; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 112..143
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 285..411
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 463..633
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT DOMAIN 705..783
FT /note="GEVED"
FT /evidence="ECO:0000259|Pfam:PF20009"
SQ SEQUENCE 790 AA; 89018 MW; F092D9EAA4FF3FBD CRC64;
MRLLKLLKIN SNIKILLSIF MISILFSCKD KQGPGVESWL WVLNPVQLDS KALSERTYTS
DGRITFAKFN SDLVPYSRKQ APEVLKTYLQ LPLSSEASFL RSARVGDFDQ DRFQQRYKGI
RVENGIYTVV SKENTIELMM GEFYQVPENF NSSPKLSESE ALSKTLKHIG AKKYLWEVSE
REAALKRKKN DPNASYFPKG ELLVYEHSLG KSNTKKEFRL AYKFGIASID PPISRYVYVD
SNSGEILSSK DARRYEGVQF PSPKPPIDID YSRCIIDREY CIEQGTAMTR FSGLQSITTW
TAGKTNHFEL KDNSRGGGIY TYSWEFVKDP LEDIQLLNIP MIDTNNSWSQ SEYHDNYNHD
ALLDAHWGIE MTYDYFKSIH NRLSYDGDNS RIFNNVHYFN AFVANNAYWD PVTEEIYYVY
CPHKNSICKG FNLPILLDPT YEDFTSLDIV SHEFGHGING DLAGFNLDME PGALDEGFSD
IWNVGVNNYV NKVLGMQKNI WLVGDETVPG GGMRSVSNPK STTVMSPGPN TYHGDLWDFE
DNEAHTNSLV LSHWFYTLSK GKQGFNDYEC TYNVSGIGIE KAERIAYVAL LFLSSTSGYT
SARTYAIIAA KLLYGLFSSE VKSTIDAWDA VAVPAETTSR GGQGMVRPRH YIASVKLSNV
TNDSGNDCGY KDNSYLLPTV LRGVTYNMVL LSQGSASNPS KVHKWRVWID FNQNGSFESS
EMVVQDTVNS SFGGTLQKSI KIPTNALTGY AKMRVSMKAA QSGEAYQGSS ESFVEGEVED
YIVSILDFSL
//
