ID M6H822_LEPIR Unreviewed; 791 AA.
AC M6H822;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Thermolysin metallopeptidase, alpha-helical domain protein {ECO:0000313|EMBL:EMM93215.1};
GN ORFNames=LEP1GSC158_4875 {ECO:0000313|EMBL:EMM93215.1};
OS Leptospira interrogans serovar Zanoni str. LT2156.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1001601 {ECO:0000313|EMBL:EMM93215.1, ECO:0000313|Proteomes:UP000012089};
RN [1] {ECO:0000313|EMBL:EMM93215.1, ECO:0000313|Proteomes:UP000012089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2156 {ECO:0000313|EMBL:EMM93215.1,
RC ECO:0000313|Proteomes:UP000012089};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Tulsiani S.M., Graham G.C., Burns M.-A.,
RA Dohnt M.F., Smythe L.D., McKay D.B., Craig S.B., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMM93215.1}.
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DR EMBL; AFMF02000038; EMM93215.1; -; Genomic_DNA.
DR AlphaFoldDB; M6H822; -.
DR Proteomes; UP000012089; Unassembled WGS sequence.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR045474; GEVED.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF20009; GEVED; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 108..141
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 287..459
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 464..635
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT DOMAIN 706..784
FT /note="GEVED"
FT /evidence="ECO:0000259|Pfam:PF20009"
SQ SEQUENCE 791 AA; 89467 MW; 4648665BD253DA30 CRC64;
MENFKWLRID LRLKILICIF SILFSCKDNK QEFGESWISL FNNVKMDEKA ISDHHYSSDG
TLTFATFNSD LVPYNRKQAP EVLKTYLQLT LNSEPVFLRS NHIGDYDHDR FQQRYKGIKV
ENGTYTVVSK RNTIESMMGE FYQVPENFNS SPKLSESEAF SKALKHFGAK KYIWESPERE
EAFKKKQDDP SATNFPKGEL LVYQHSLGKL NSQKEFRLVY KFGIVSIEPS FSRYVYVDSH
SGEILANVDA NRYEAGGGDT TPTTPQTPPD THYGICFPDK TPCIKQGTAA TRFSGIQSII
TWTTEADHFE LKDYSRGKGI VSYSWEFVRV APSALETVKI PLIDTDNNWT KAEYHDDYNH
DAVLDAHWGI EHTYDYFKSV HNRSSFDGED AKIVNNVHYT KVLNFNNAHW NPITEELEYT
YCPHDSSLCH GINDEILLDP RFEDFTSLDI ASHEFGHAIN AYAAGFDYNA ESAALDEGFG
DIWNVGVNHY VNKILGMHKN VWRFGDETVL NGGMRSLQYP NSATPVTLGG ADTYYGDLWD
FTNKKTHENG LVLGHWFYIL SNGKSGINDH SCEYNTTGIS IEKAEKIAYS TIHYLSPTSG
YVATRSAAIL AAKNLYGKFS SEVKSTIDAW DAVGVPAETT SRGGDGMRKV GNYITSVKLS
GMENNSGNDC GYKDNTYLHP WVLKGGTYQL VLSSEGSQLP LKSHKWSVWI DLNRNGIFDS
SEIILQTSNQ LWGEGTLQRS IVIPTTALTG NTKMRVSMKS ADSWEAYPRA DEKFYDGEVE
DYTISINSFR L
//
