ID   M6HQU1_LEPIR            Unreviewed;      1067 AA.
AC   M6HQU1;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=LEP1GSC158_3574 {ECO:0000313|EMBL:EMM97767.1};
OS   Leptospira interrogans serovar Zanoni str. LT2156.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1001601 {ECO:0000313|EMBL:EMM97767.1, ECO:0000313|Proteomes:UP000012089};
RN   [1] {ECO:0000313|EMBL:EMM97767.1, ECO:0000313|Proteomes:UP000012089}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2156 {ECO:0000313|EMBL:EMM97767.1,
RC   ECO:0000313|Proteomes:UP000012089};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Tulsiani S.M., Graham G.C., Burns M.-A.,
RA   Dohnt M.F., Smythe L.D., McKay D.B., Craig S.B., Vinetz J.M., Sutton G.G.,
RA   Nierman W.C., Fouts D.E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMM97767.1}.
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DR   EMBL; AFMF02000010; EMM97767.1; -; Genomic_DNA.
DR   AlphaFoldDB; M6HQU1; -.
DR   Proteomes; UP000012089; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EMM97767.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          249..350
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
SQ   SEQUENCE   1067 AA;  123592 MW;  A810AB603AAE99FD CRC64;
     MENSNPVPLQ RILKLQYGDP SKFEDLFERK DISKKFYQEF NRQKIALGNS IHGITNPEDK
     KLYAQILLDR LIFLFFLQSK NLLNENPRYF AEKYREYSQK KNAFYETFLK ELFFNALCRK
     ERENTTLEIV GKSIPYLNGG LFLKHELEEK YPKIQVANET FAEIFRFFES WNWNVNERSE
     TDEDSIDPYI LGYIFENTLV DNKSGGVYYT PASLSEFLTD ETIEGHLFTN LKSASGPYKD
     TLEFIEKATE KELFFFYETL RTITICDPAC GSGQFLVQAL HSLSFYHSRF VQRIQKEGWE
     ELKTYVQKDY SIEKDPTYGI RRHIAAKNLY GVDILPEAAE ITKLRLFLAM VEGIGNASET
     LEPLPNIDFH IRSGNSLTGF LFLPEDFFKA LSATRAKGKK NSAEERILDF GDAESKMLKK
     DKLVTLYTNE PSPEEALKLR KEIREIDLEL QNVLNQRLEQ KMSEWKVRPK KKIDFIDEKK
     DLKAKEILNR FVLKTEEIKP FHHGMEFSTI LHPSNPNLPG FDIVLMNPPW DVLQPDSKEY
     FEKHIKDVRG FDKNVAKIKI PDILKSNPSL KQAWIQFNLE ISSYSDLINK SNFFPNSKGG
     KINLYKLFLE RGWNLLKEGG SLGIVIPAGL YSDLGSKDLR KMLFQEGKIH FLYGFENRKQ
     LFENVDSRFK FILLSATKQT DSPASSVPAA FMLHTESDLH SVHENNRKKQ ESTLEVSKSD
     PSADRRFLDL PIELITRLSP DSLSLMEFKS DTDIHIVEKM AKFPRLGEEL EGTWNVKLSS
     EFNMTTDSYL FFTQEVLKKK GAQYDPETMI WKNGKEEWWP LYEGRMVTQY DHRAASYVSG
     SQRSAVWNYL NFPKLSNVNP HYWIIPQEKN KVGYKIYICD VTGSSNKRTG LATVVKRNES
     SGNSLAIIDT DNLQINLLLT GLINSFSLDF YVRLRIPGNH YNQAVIFDLP TPRYLNEDSK
     LQKEKHTQGS QQYFAFRNDL IQTTARLVGT TPAFDELLQE VFGPKANHKT HGVTDPAQRQ
     ILKNQIDAMV AKIYGLEEAE LKHILSTFPL VEEEIKEGVL EEWRKLK
//