ID M6Q607_9LEPT Unreviewed; 567 AA.
AC M6Q607;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:EMN88620.1};
GN ORFNames=LEP1GSC108_4610 {ECO:0000313|EMBL:EMN88620.1};
OS Leptospira weilii str. UI 13098.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1088542 {ECO:0000313|EMBL:EMN88620.1, ECO:0000313|Proteomes:UP000012118};
RN [1] {ECO:0000313|EMBL:EMN88620.1, ECO:0000313|Proteomes:UP000012118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UI 13098 {ECO:0000313|EMBL:EMN88620.1,
RC ECO:0000313|Proteomes:UP000012118};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Chanthongthip A., Lattana O.,
RA Phetsouvanh R., Newton P.N., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMN88620.1}.
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DR EMBL; AHNU02000077; EMN88620.1; -; Genomic_DNA.
DR RefSeq; WP_004504099.1; NZ_AHNU02000077.1.
DR AlphaFoldDB; M6Q607; -.
DR Proteomes; UP000012118; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT DOMAIN 1..183
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 225..448
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 567 AA; 64875 MW; A3E9C45DAA2EFA9C CRC64;
MRLLLIQPPV QDFYDTDIRL QPIGLCYLKG AVQKFLPNIE VIIRDFHRGL GDKLAGRRTV
PIPSELRYLK EYYPVPDKSP FSTFFEYFHF GAPYEDIANE VKSLTPDLVG ISSLFSPYYR
EALKTAETVK KVLDVPVLMG GSHVSACPEL MLSNPNVDFI IRGEGEKPIC DFLREFQAHK
RYAIVDSLGW KENGTLRLNP IGDNFPIQEL PPPDVSSLLK EHYLFEGKPI RFVITSRSCP
HRCSFCSVHT TFGTKYRRNT VENVLSEIKE SYELGYRVFD FEDDNLTFFR PEMKKLCEEL
IRAFPKKDVR FVAMNGISYI SLDSELLCLM KDAGFTNLNL ALVSSDKLVR ETTKRPHTIE
KYLQIVRESF ELGFQITSYQ ILGLPMETLE SMIQTLRFNT AQPVLMGASL FYLTPNSPIA
SDFPERNESD VFLSRLTSMA ISSEHFERED IYSLFIVTRI LNFLKSVSVS KGNTVSLNEA
LRILEKCGIR SLVGVRLFEK LLDEKKLYAS TSQDWILLEK FRYEVFEKVF SGLDGICTLS
GGKIDLQDLN RFLPLCNTNS EPSSNSY
//
