ID M6QHR4_9LEPT Unreviewed; 1171 AA.
AC M6QHR4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN ORFNames=LEP1GSC108_1980 {ECO:0000313|EMBL:EMN88467.1};
OS Leptospira weilii str. UI 13098.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1088542 {ECO:0000313|EMBL:EMN88467.1, ECO:0000313|Proteomes:UP000012118};
RN [1] {ECO:0000313|EMBL:EMN88467.1, ECO:0000313|Proteomes:UP000012118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UI 13098 {ECO:0000313|EMBL:EMN88467.1,
RC ECO:0000313|Proteomes:UP000012118};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Chanthongthip A., Lattana O.,
RA Phetsouvanh R., Newton P.N., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMN88467.1}.
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DR EMBL; AHNU02000081; EMN88467.1; -; Genomic_DNA.
DR AlphaFoldDB; M6QHR4; -.
DR Proteomes; UP000012118; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
FT DOMAIN 6..273
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1171 AA; 133073 MW; 812D50AF13D16EF7 CRC64;
MKIEGYEIKE RMNTDSSTEV YKAVRSKDGI NVIIKYIPIL DELHPAVVNL RNEYEILNYL
SSDKMIQAFG MEKIPEGFTL ILEFVPGESL KQFSKKKPVN LNDFFKIAID LTEKLGEIHN
KKVIHKDLKP DNIIFNPDED ILRIVDFGIS TRLSKEETSW SNPNRLEGSI HYVSPEQTGR
MNRSVDYRSD FYSLGVTFYE LLTGKLPFES EDLLELVHFH LAKSPVDPRK VRGEIPEALS
HVVLKLLSKT AEERYQTSEG LKSDLETIRD KWLESGDVPS FPLGSTDYSH EFKIPQKLYG
REGYIEALLN EFKRMTETGR TSVVLIAGYS GVGKSSLVKE INKPLTESKG YSISGKFDQY
NRNVPFSAII QVFSNLIEQI LTESPERIED WKNKIRTTLG LNGKVITDVL PELEFIIGEQ
PPVAELGPQE NANRFYLVFQ NFIKIFANQD HPLAIFLDDL QWADTSSLEL VKNLIEDASV
NYIFLILAYR DNEVDSTHPF STLITGLEKE GFRLDKILLK PLSLENVNEL LSDSLRKPIE
ETLSFAEIVY SKTRGNPFFI NELLKQLSKE EVISYQQGSS AISGGWIWDL DKIKKTDISD
NVVDLLVKRI KKLSPRTQET LKFASCIGSN FDLGIQSKIL GATLKETAAA LMETMEEELI
VPIGDNYRLV DSMVEIEENQ DKNFQIAKSI QFRFQHDRVQ QASYELLNED QKRSLRLKIG
RILLENLNEK ALEDSIFDVV NHLNTGSLLV TENSEKRKLI QLNLQAAQKA KLSAAYKPSK
LYSEKARELL LSLSKSGKDD KVLWEKEYDL AYAVHKELAE ALYLNGSFEE SQEMIQNILK
QAKTPVEQAE AYNLLMIEYS AQGKYDLAMP TVIKALKPLG IELPISGFEK VVKKEIEEAK
KNLKNRNITS LLDAPLMTDP NHIWAVNLLI SAIPMAYNKE PALFPVICLK MANLLLKYGN
LSDSYGYSCY GMVLVGKLGD YKGAYDFCEL AVKLSEKYMN SGGYTKAANI LANYSSSFVK
HLKFSEEVNI KCVQAALDSG EFLHGSYAAM NDASNVMFQG KNLEILKPKI NQLLKFVRKV
KNNLAIDTIL GTILILSNLR GETGSHLDFS SSEYLEKEYI DLCNDHQSLA PICTEPPPNE
WTRSCKLKKD KAWLVKHNTT KNLRRTRLNF W
//
