ID M6RIC6_LEPIR Unreviewed; 681 AA.
AC M6RIC6;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=7TM diverse intracellular signaling {ECO:0000313|EMBL:EMO04364.1};
GN ORFNames=LEP1GSC116_5228 {ECO:0000313|EMBL:EMO04364.1};
OS Leptospira interrogans serovar Icterohaemorrhagiae str. Verdun HP.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049910 {ECO:0000313|EMBL:EMO04364.1, ECO:0000313|Proteomes:UP000012092};
RN [1] {ECO:0000313|EMBL:EMO04364.1, ECO:0000313|Proteomes:UP000012092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Verdun HP {ECO:0000313|EMBL:EMO04364.1,
RC ECO:0000313|Proteomes:UP000012092};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Picardeau M., Werts C., Goarant C.,
RA Vinetz J.M., Sutton G.G., Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMO04364.1}.
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DR EMBL; AHNZ02000664; EMO04364.1; -; Genomic_DNA.
DR AlphaFoldDB; M6RIC6; -.
DR Proteomes; UP000012092; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 2.60.40.2380; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR011622; 7TMR_DISM_rcpt_extracell_dom2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF07696; 7TMR-DISMED2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..681
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004078209"
FT TRANSMEM 180..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 443..569
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 681 AA; 78126 MW; 31A16364628425EB CRC64;
MKIIKILRIV FPILLTLPTF AETIPWNENQ VRLGIYSQIL EDQDSSLTIE SVQNKEFQQS
NQTNPSFGFT KSAYWLKFSF NNPEETFKEK LLEITFPLID EVILYSPENG TYQQTIVGIE
KPFTDRPIES HTFVFPIHAP PGVSTFYLRF KNEDSMQMPL ILWEPDAFYK NIRDIQYING
IYFGILIAMA VYNLFLLLTV RDKSYFFYVF YILCFAIFLM SQYGFAYEYL WPEFSWGARR
MNPFLAGLLE FSILLFTRDF LDTKNTFPTL HKYNHVLIIL CAMASFSSFF VNLTQGALQV
AILGLLTAIS ILASGIKALM SGFRPARYFM IAFSALLLGG AFYALKTIGA IPVSFVTEYS
MQIGSGLEVT LLSLGLGDRI SILIKEKQET QKELIREQND SIEKQAKLNE SFARFVPSKL
IHLLGKNEVI QVALGDQIQK EMTVLFSDIR SFTELSESMN PQENFNFLNS YLERMTLAIE
KYSGTIDKFI GDAIMALFET NAEDGLMAAI EMHRQLKLYN ADRDRQGYKP IETGIALHKG
PVMLGTIGSQ NRMEVTVISD TVNTTSRIEG LTKNYGAKIL LSETAFSSLK DPSQFLYRYL
GRTFVRGKKE DLSILEFCDT ESDEAEQFFK TKSKFEKGVF HFFEEEYTFA FNHFRDVLSE
YPTDSASAWY LQACRTSLKR E
//
