ID M6U905_9LEPT Unreviewed; 670 AA.
AC M6U905;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=LEP1GSC186_2113 {ECO:0000313|EMBL:EMO41492.1};
OS Leptospira noguchii serovar Autumnalis str. ZUN142.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1085540 {ECO:0000313|EMBL:EMO41492.1, ECO:0000313|Proteomes:UP000012153};
RN [1] {ECO:0000313|EMBL:EMO41492.1, ECO:0000313|Proteomes:UP000012153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZUN142 {ECO:0000313|EMBL:EMO41492.1,
RC ECO:0000313|Proteomes:UP000012153};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Matthias M.A., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMO41492.1}.
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DR EMBL; AHOP02000021; EMO41492.1; -; Genomic_DNA.
DR AlphaFoldDB; M6U905; -.
DR Proteomes; UP000012153; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF3; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:EMO41492.1};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 10..294
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 295..557
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 31..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 670 AA; 76277 MW; 70C5C6D9DFD41199 CRC64;
MDITIIERVE ELNPAQMEAV LTQDGPVLVL AGAGTGKTKT IVSRLAQLVS SGIPASSILL
LTFSRKAARE MILRASTIGN KKCSEVQGGT FHSFCNGVLR KFAPVLDISS GFTILDESDC
LDVFQFLRNE KNFGKTKSRF PSNETLVSIH SEIQNTGKPL RSILEKDYPL FLQKTEDISQ
IFEDYKFYKK EQSFLDYDDL LYFTRDLLAN HPGVRNAISE KYRFIMVDEF QDTNKIQAHI
ACLLASEHSN LMVVGDDAQC IYTFRGASVR GILDFPKIFP NTKTIFLEKN YRSTPSILNL
ANEVLKNFSE KYDKYLFTDN ENGLIPQVLQ FEDELEEAEG ISKILLEKRE EGIPFQKMCV
LFRAGWNSNQ LELVLAKRNI PFVKFGGKKF IETAHIKDLL SLLKLLVNPL DSISWLRTLK
LIPGIGNAKA NFILDKIRKS SGSFEALSEE NETTIGKYLS PLYHLYQKYK ETHSEVKKMV
SEFIDYYRVL LEKNYDDSKR RSEDLDAVLG FSLKYNSLND FLSDLTMDPT SLSLDKMKPD
DTDSDLLNLS TVHSAKGLEF DVVFVLNTTE GIFPSSKNTD IEEERRLFYV AITRARKELY
LTRPSLAQSR SGPYYTKLSR FLSEIQFPEK VYELKLISGK SVSKNSFVSQ DSSVKSKNDS
FSRIQDYFGN
//