ID M6UU61_9LEPT Unreviewed; 513 AA.
AC M6UU61;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=hsdM {ECO:0000313|EMBL:EMO46311.1};
GN ORFNames=LEP1GSC187_1002 {ECO:0000313|EMBL:EMO46311.1};
OS Leptospira santarosai str. ZUN179.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049985 {ECO:0000313|EMBL:EMO46311.1, ECO:0000313|Proteomes:UP000012160};
RN [1] {ECO:0000313|EMBL:EMO46311.1, ECO:0000313|Proteomes:UP000012160}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZUN179 {ECO:0000313|EMBL:EMO46311.1,
RC ECO:0000313|Proteomes:UP000012160};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Matthias M.A., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMO46311.1}.
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DR EMBL; AHOQ02000019; EMO46311.1; -; Genomic_DNA.
DR RefSeq; WP_004485754.1; NZ_AHOQ02000019.1.
DR AlphaFoldDB; M6UU61; -.
DR Proteomes; UP000012160; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EMO46311.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EMO46311.1}.
FT DOMAIN 10..158
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 171..479
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 513 AA; 57511 MW; A0E0487BB6E30358 CRC64;
MTSAQQRAAL QRQIWQIAND VRGAVDGWDF KQYVLGTLFY RFISENFTNY MEGGDSSIDY
AKLPDKRITR EIKDDAIKTR GYFIYPSQLF ANVVSKADDN ESLNTDLAAI FKAIETSANG
FPSEHDIKGL FADFDTTSNR LGNTVKEKNS RLAAVLKRVA ELDFGDFDSS HIDLFGDAYE
FLISNYAANA GKSGGEFFTP QHVSKLIAQL AIHKQTRINK IYDPACGSGS LLLQAKKQFD
DHIIEEGFFG QEINHTTYNL ARMNMFLHNI NYDKFDIALG NTLIDPQHNN EKPFDAIVSN
PPYSINWKGS DDPTLINDDR FAPAGVLAPK SKADFAFVLH ALNYLSSKGR AAIVCFPGIF
YRGGAEQKIR QYLVDNNFVE TVISLAPNLF FGTTIAVNIL VLSKHKTDTN TQFIDASGLF
KKETNTNILT DEHIEQIMQT FDSKIDKEHF AKSVSMEAIA KNEYNLSVSS YVEAKDNREV
IDIQKLNAEL KTTVKKIDQL RADIDAIVAE IEG
//
