ID M6Y7A7_9LEPT Unreviewed; 411 AA.
AC M6Y7A7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit / precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiT subunit multi-domain protein {ECO:0000313|EMBL:EMO89625.1};
DE EC=2.1.1.132 {ECO:0000313|EMBL:EMO89625.1};
GN ORFNames=LEP1GSC024_2183 {ECO:0000313|EMBL:EMO89625.1};
OS Leptospira noguchii str. 2001034031.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1193053 {ECO:0000313|EMBL:EMO89625.1, ECO:0000313|Proteomes:UP000012138};
RN [1] {ECO:0000313|EMBL:EMO89625.1, ECO:0000313|Proteomes:UP000012138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2001034031 {ECO:0000313|EMBL:EMO89625.1,
RC ECO:0000313|Proteomes:UP000012138};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Whelen A.C., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMO89625.1}.
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DR EMBL; AKXB02000091; EMO89625.1; -; Genomic_DNA.
DR RefSeq; WP_004426014.1; NZ_AKXB02000091.1.
DR AlphaFoldDB; M6Y7A7; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000012138; Unassembled WGS sequence.
DR GO; GO:0046025; F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR030382; MeTrfase_TRM5/TYW2.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR NCBIfam; TIGR02469; CbiT; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF02475; Met_10; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EMO89625.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EMO89625.1}.
FT DOMAIN 4..191
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 251..308
FT /note="SAM-dependent methyltransferase TRM5/TYW2-type"
FT /evidence="ECO:0000259|Pfam:PF02475"
SQ SEQUENCE 411 AA; 45195 MW; AACDC17245C1A56C CRC64;
MKAVTVVGMG DEGCPGLSSI AVNAIAKAQI LAGGKRHLDF FPQFSGEKIV LKDDLIQTIK
KIAELSLEHT ICVLASGDPL FFGIGNLIRK KVGPEYIDFI PAPSSVQHAF AKIGIPWDDA
EVLSLHGRSA KGLITKLQFC NKVALFTDKI NHPKEIASYL LSFKESDWTA FVCENLGGEK
ERIRKFDLKS LSEVDGIDPL NVLILIRNSI NWKPPPVVPN VSEESYSKRV PKKGLITKKE
VRILSIAFLN IREDSIIWDI GAGSGSIAIE AAQIAKNGKS YAIEVDPEGI EICKQNIVFQ
KTDNVYVVSG KAPEVLEKLP DPDCVFVGGS NGDIYEIIRI SLNRLSSLGS LVANAVTIDN
VSQIYQSFKK LKLVPEVTLL NVSRGQVLKD YLRYEALNPI HIFKITKPEK T
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