ID M6YCY8_9LEPT Unreviewed; 915 AA.
AC M6YCY8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00017562};
GN ORFNames=LEP1GSC024_3255 {ECO:0000313|EMBL:EMO91620.1};
OS Leptospira noguchii str. 2001034031.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1193053 {ECO:0000313|EMBL:EMO91620.1, ECO:0000313|Proteomes:UP000012138};
RN [1] {ECO:0000313|EMBL:EMO91620.1, ECO:0000313|Proteomes:UP000012138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2001034031 {ECO:0000313|EMBL:EMO91620.1,
RC ECO:0000313|Proteomes:UP000012138};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Whelen A.C., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMO91620.1}.
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DR EMBL; AKXB02000001; EMO91620.1; -; Genomic_DNA.
DR RefSeq; WP_004442212.1; NZ_AKXB02000001.1.
DR AlphaFoldDB; M6YCY8; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000012138; Unassembled WGS sequence.
DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR001249; AcCoA_biotinCC.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR48095:SF4; BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR48095; PYRUVATE CARBOXYLASE SUBUNIT A; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR PRINTS; PR01071; ACOABIOTINCC.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 25..591
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 800..890
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 915 AA; 102312 MW; 4A9C880A09658FD7 CRC64;
MIDFQNNRIQ FHQSSSPWIR SFSLESIKCL IVCRGPVRKE AMEIFDSIGI REYGILLSEK
DSVVYPMALA PELRGFRFPN NIHRVPDYMG AGKEEKMERI EQIISIAKDN KYTHIFAGYG
FMAEDSEFIS AIEKSGVVFM GPASYVADQA GSKDAAKKIA RKLEVSVTPG VDNISSLALL
TKAPDAKSLE KIAKEKGIDF TFDSSLSLEL NAENLLELGY SKIIELVSIT DLQTEAEKEC
KKIWEKYSKN RIRFKYIGGG GGKGQRVVSK PEEVKGAVQE ILSESKVTAP GTNKNFLIEL
NIENTRHNEI QLIGNGEWCL ALGGRDCSVQ MHEQKLLELS LTQELLEKEI AVCAATHPKK
AEVLKGDLKV LREMEEQSER FGAAVKLNSV STFESIVEGT NHFFMEVNTR IQVEHRVTEM
VYSLKFKNPE NQNEFFIVDS LIEAMALLSL HGKRLQKPDR IFRYPSGAEV RINATNKAIQ
PHAGGVIMNW SKPIADEIRD DQGISIRNPD MGLFVHYKVA GAYDSNIALL ISHGENRKDN
LIRLGNILRK TELRGYDLQT NLLVHYGLIH WILGKDAMFK PSTSFMISYL AGVGALEKII
KDVDLEIAWK KMISEAPSTD LKKVLSRKLT LITRPIGELI KDSHLTAGFI GFHLNRSWKI
SGSKIEWLRN PIFILADLYH YLNMEADPSL PPSEQIWDHD DEVLQKAISF YQELAKRTGI
SADSIELVTS LNSGKSLSGI ESGLSSSVLA SHNGYQAGLE LLKLLPYAGL NSGFYNLEVD
EKLEAVIPEE FKKVEIRDSL IKFLAPPPKA SSDEIVAPMG GMFYSKEAPD LPPMVKVGDH
FKAGQPLFIV EVMKMFNKIS APFSGTVKEI LLNDSDGKII SKGQTIFKIV PDEVIHIETE
TEIAERKKKV TLSLI
//
